Synthesis and microbiological activity of some 4-butyl-2H-benzo[1,4]thiazin-3-one derivatives. |
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| Authors: | V L Guarda M Perrissin F Thomasson E A Ximenes S L Galdino I R Pitta C Luu-Duc |
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| Affiliation: | Escola de Farmácia, Universidade Federal de Ouro Preto, MG, Brazil. vera@cpd.ufop.br |
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| Abstract: | The synthesis and physicochemical properties of 4-butyl-2H-benzo[1,4]thiazin-3-one derivatives are described. These new compounds were synthesised by alkylation in 4-N position and acylation and/or alkylation of 6-NH2 by phase transfer catalysis. Acid hydrolysis of 6-alkylacylamino group yielded 6-alkylamino-4-butyl-2H-benzo[1,4]thiazin-3-ones. The antimicrobial in vitro activity was determined on five compounds. |
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