黄芪注射液对银屑病患者T淋巴细胞亚群及细胞因子的影响 |
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引用本文: | 吴媛,;甄莉,;张荣丽. 黄芪注射液对银屑病患者T淋巴细胞亚群及细胞因子的影响[J]. 山西临床医药, 2009, 0(6): 408-410 |
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作者姓名: | 吴媛, 甄莉, 张荣丽 |
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作者单位: | [1]山西医科大学第二医院,山西太原030001; [2]山西医科大学第一医院,山西太原030001 |
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基金项目: | 本课题为山西省青年基金项目(课题编号:20011030). |
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摘 要: | 目的:探讨黄芪注射液治疗银屑病的机制。方法:对20例进行期寻常型银屑病患者应用黄芪注射液治疗,10名健康志愿者作为正常对照组,分离外周血淋巴细胞与血清,应用流式细胞仪和ELISA测定,观察患者治疗前后和正常对照组各指标的变化情况。结果:与正常对照组相比,病例组治疗前IL-2,sIL-2R,CD4^+T,CD4^+T/CD8^+T含量升高(P〈0.05),CD8^+T,mIL-2R表达下降(P〈0.05);治疗后,IL-2,sIL-R,CD4^+T,CD4^+T/CD8^+T含量降低(P〈0.05),CD87T,mIL-2R表达升高(P〈0.05)。结论:黄芪注射液是治疗进行期银屑病的一个有效药物,它的治疗作用可能是通过调节细胞因子的表达,抑制T淋巴细胞而实现的。
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关 键 词: | 黄芪注射液 银屑病 T淋巴细胞 细胞因子 mIL-2R IL-2 sIL-2R |
Effects of Astragulus injection on T-lymphocytes and cytokines in patients with psoriasis |
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Affiliation: | WU Yuan,ZHEN Li,ZHANG Rong-li (The Second Hospital of Shanxi Medical University,Taiyuan 030001 ,China) |
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Abstract: | Objective:To study the mechanism of Astragulus injection on treating psoriasis. Methods:Twenty patients with acute psoriasis vulgaris were treated with Astragulus injection. By flow cytometry and enzyme linke immunosorbent assay(ELISA) ,the changes of T-lymphocytes subsets and cytokines in peripheral blood from 20 patients with psoriasis and 10 normal control were detected. Results :The number of CD4^+T ,CD4^+T/CD8^+T ,1L-2 ,sIL-2R in patients increased signifficantly and the expression of mIL-2R and CD8^+T decreased signifficantly than those of normal controls. Compared with untreated patients group,the number of CD4^+T,CD4^+T/CD8^+T, IL-2 ,sIL-2R in patients treated with Astragulus injection decreased signifficantly and the expression of mIL-2R and CD8^+T increased signifficantly. Conclusion : Astragutus injection is effective in the treatment of acute psoriasis vulgaris. Its mechanism treating psoriasis might be regulation of cytokines and suppression of T-lymphocytes. |
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Keywords: | Astragulus injection psoriasis T-lymphocytes cytokine mIL-2R II.-2 sIL-2R |
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