乳腺癌腋淋巴结微小转移与C-erbB-2，nm23基因表达关系的相关性研究

目的：探讨乳腺癌腋淋巴结微小转移与C-erbB-2，nm23基因表达的关系。方法：采用免疫组织化学S—P法对78例淋巴结常规HE染色无癌转移的乳腺癌淋巴结1269枚进行上皮细胞角蛋白（CK19）表达和癌组织进行C-erbB-2，nm23基因表达的检测。结果：淋巴结CK19阳性率为4．25％，其病理阳性率为28．2％，C-erbB-2阳性率为43．6%，nm23阳性率为80．8％，CK19阳性组的C-erbB-2阳性率明显高于CK-19阴性组（P〈0．05）。CK-19阳性组的nm23阳性率明显低于cK-19阴性组（P〈0．05）。CK-19阳性率与患者月经状况、病理类型、临床分期、激素受体状况无关（P〈0．05）。结论：乳腺癌腋淋巴结CK19表达与癌组织C-erbB-2基因表达呈正相关，与癌组织nm23基因表达呈负相关，与患者月经状况、临床分期、病理类型、激素受体状况无关。

The relationship of micrometasis in axillary lymph node and c-erbB-2,nm23 gene in breast cancer

Objective：To investigate micrometastasis in axillary lymph nodes and its relationship with c-erbB-2, nm23 genes expressin of the tumor tissue in breast cancer. Methods ：Total of 1 269 lymph nodes and carcinoma tissues from 78 lymph node negative cases comfimed by routine pathology were examined by immunohistochemical staining using CK-19 and c-erbB-2,nm23 respectively. Results ：The positive rate of CK-19 of axillary lymph node was 4. 25%. Micrometastasis were observed in 22 cases of the 78 patients （28.2%）. The positive rate of c-erbB-2 was 43.6% ,the positive rate of nm23 was 80. 8% in breast cancer tissues. The positive rate of c-erbB-2 in the patients with micrometastasis was significantly higher than that in the patients without micrometastasis （P〈0.05）. The positive rate of nm23 in the patients with micrometastasis was significantly lower than that in the patients without micrometastasis （P〈0.05）. There was no significant relationship with patient menstruation condition,clinical stage,pathologic type, hormone condition irrelevant to CK-19 expression. Conclusion：The expression of CK-19 of axilliariy lymph node is positive relevant to C-erbB-2 gene with cancer,neganative relevant to nm23 gene with cancel The expression of CK-19 of axilliariy lymph node is irrelevant to patient menstruation condition,clinical stage ,pathologic type ,hormone condition.