中国人群大样本调查乙型肝炎病毒感染血清学标志物检出模式分析

目的分析中国（未包括香港、澳门特别行政区和台湾地区,下同）不同年龄和免疫状态人群乙型肝炎（乙肝）病毒（Hepatitis Virus,HBV）血清学标志物检测组合模式。方法在全国160个疾病监测点,采用多阶段随机抽样方法,抽取1～59岁常住人口作为调查对象。问卷调查后,采集血标本,分离血清后用酶联免疫吸附试验检测乙肝病毒表面抗原（Hepatitis B Surface Antigen,HBsAg）、抗乙肝病毒表面抗原抗体（Anti-hepatitis B Surface Antibody,Anti-HBs）、抗乙肝病毒核心抗原抗体（Anti-hepatitis B Core Antibody,Anti-HBc）。对HBsAg阳性标本进行乙肝病毒e抗原（Hepatitis B e Antigen,HBeAg）和抗乙肝病毒e抗原抗体（Anti-hepatitis B e Antibody,Anti-HBe）检测。结果全国1～59岁人群HBsAg、Anti-HBs、Anti-HBc、HBeAg、Anti-HBe的组合模式共检测出16种,在1～4岁儿童以单纯Anti-HBs为主,占69.77%;15～59岁人群以全阴性检测结果多见。有免疫史人群中,年龄越大,Anti-HBs检出率越低;未免疫人群除检测指标以全阴性和单纯Anti-HBs外,自然感染所致的标志物多见。结论检测结果为其他流行病学调查提供了参考,可分析不同年龄、不同免疫史人群HBV血清学标志物的检出情况。

Combination Profiles of Hepatitis B Marks for Chinese in Serosurvey in 2006

Objective To summarize the combination profile of hepatitis B markers by age and immunization history of Chinese. Methods Population of age 1-59 years were sampled from 160 counties of National Disease Surveillance in 31 provinces by multi-stage random sampling method. Demographic information and hepatitis B vaccination history was collected by questionnaire,and 2-4ml serum sample was taken for testing HBsAg,Anti-HBs and Anti-HBc by ELISA method. Results 16 combinations of hepatitis B markers （HBsAg,Anti-HBs,Anti-HBc,HBeAg and Anti-HBe） were found during the testing,anti-HBs was mainly found among 1-4 years old children,accounted 69.77%. Among 15-59 years,negative markers were mainly profi le. Among immunized population,the older,the lower rate of anti-HBs,while among un-immunized population,except negative for all markers and anti-HBs were observed,Infected markers was account for high proportion. Conclusion The prof ile could be used for guiding the laboratory testing by different ep.idemiologic characteristics,and can provide information for reference.