| 二膦酸盐在成骨不全疾病中的应用 |
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| 引用本文： | 王熙然,裴育,窦京涛,陆菊明. 二膦酸盐在成骨不全疾病中的应用[J]. 国际内分泌代谢杂志, 2009, 29(3). DOI: 10.3760/cma.j.issn.1673-4157.2009.03.009 |
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| 作者姓名： | 王熙然 裴育 窦京涛 陆菊明 |
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| 作者单位： | 第二炮兵总医院内分泌科;解放军总医院内分泌科,北京,100853 |
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| 基金项目： | 北京市自然科学基金，解放军总医院苗圃基金 |
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| 摘 要： | 成骨不全是一种以脆骨症为典型特征的遗传性结缔组织疾病,该病最严重的后果为骨脆弱所导致的频繁骨折、继发性骨骼畸形,90%的成骨不伞是I型胶原基因突变所致.临床研究证实,二膦酸盐可抑制破骨细胞活性,增加骨密度、降低骨折发生率、改善患者生活质量,是目前内科对成骨不全治疗的有效手段.本文就二膦酸盐的作用机制、治疗方法、疗效、不良反应及存在的问题等予以综述.
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| 关 键 词： | 成骨不全 I型胶原 二膦酸盐 治疗 |
Bisphosphonate in the treatment of osteogenesis imperfecta |
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| WANG Xi-ran,PEI Yu,DOU Jing-tao,LU Ju-ming. Bisphosphonate in the treatment of osteogenesis imperfecta[J]. International JOurnal of Endocrinology and Metabolism, 2009, 29(3). DOI: 10.3760/cma.j.issn.1673-4157.2009.03.009 |
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| Authors: | WANG Xi-ran PEI Yu DOU Jing-tao LU Ju-ming |
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| Abstract: | Osteogenesis imperfecta (oI) is a genetic disease of connective tissue.The most serous consequences are bone fractures and deformities.90% patients with OI is caused by type I collagen gene mutation.Clinical research indicates that bisphosphonates can inhibit bone resorption,improve bone mass,decrease the incidence of fracture and improve quality of life.Bisphosphonates is an effective treatment for OI.This paper will outline the role of bisphosphonates in mechanism,treatment,effects,side effects and other problems. |
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| Keywords: | Osteogenesis imperfecta Type I collagen Bisphosphonate Treatment |
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