Reciprocal control of colon-specific sulfomucin and sialosyl-Tn antigen expression in human colorectal neoplasia |
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Authors: | T Yamachika Hayao Nakanishi Ken-ichi Inada Kuniyoshi Kitoh Tomoyuki Kato Tatsuro Irimura Masae Tatematsu |
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Institution: | (1) Laboratory of Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464, Japan Tel.: (81) 52-762-6111, Fax: (81) 52-763-5233, JP;(2) Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya 464, Japan, JP;(3) Faculty of Pharmaceutical Sciences, The University of Tokyo,Tokyo, Japan, JP |
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Abstract: | Histochemical reports claim that sulfomucins decrease and sialylated mucins increase during colon carcinogenesis. We examined
the expression of colon-specific sulfomucins and sialosyl Tn antigen (STN) in normal small intestine, normal colorectal mucosa
and colorectal tumours at different stages of progression immunohistochemically, using MAb 91.9H specific for colonic sulfomucins
and MAb TKH-2 for STN. No expression of sulfomucins recognized by MAb 91.9H was found in normal small intestine, whereas STN
staining was pronounced. The converse was the case in normal colorectal mucosa. Sulfomucins were still found in adenomas,
but the amounts decreased with depth of invasion in cancers (P<0.001). In contrast, no STN could be detected in benign lesions, but staining became increasingly evident with invasion (P<0.001). This reciprocal control of expression of colon-specific sulfomucins and STN evident in tumour progression indicates
that the mucous phenotype shifts from the colonic to the small intestinal type.
Received: 10 September 1996 / Accepted: 4 February 1997 |
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Keywords: | Colon cancer Colon-specific sulfomucin Sialosyl-Tn Immunohistochemistry Cell differentiation |
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