| 可吸收超高分子量聚-DL-乳酸材料的生物安全性评价 |
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| 引用本文： | 孙皎,薛淼,励永明,顾国珍,钱云芳,陆华,孟爱英.可吸收超高分子量聚-DL-乳酸材料的生物安全性评价[J].口腔材料器械杂志,2000,9(4):195-197,209. |
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| 作者姓名： | 孙皎 薛淼 励永明 顾国珍 钱云芳 陆华 孟爱英 |
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| 作者单位： | 上海第二医科大学附属第九人民医院,上海生物材料研究测试中心,200011 |
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| 基金项目： | 国家八六三计划新材料领域基金!资助 (86 3 -715 -0 0 2 -0 2 2 0 ) |
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| 摘 要： | 目的 评价一种新型的超高分子量聚－ＤＬ－乳酸（ＰＤＬＬＡ）材料的生物安全性。方法参照ＳＩＯ１０９９３的要求，对ＰＤＬＬＡ材料进行细胞毒性试验、急性全身毒性试验、致敏试验、溶血试验和Ａｍｅｓ试验。结果 ＰＤＬＬＡ材料无细胞毒性作用、无致敏性、无急性全身毒性反应、无明显的溶血现象以及Ａｍｅｓ试验无致突变性。结论 该超高分子量聚－ＤＬ－乳酸具有良好的生物相容性。
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| 关 键 词： | 超高分子量 聚－DL－乳酸 生物安全性 |
Evaluation on biological safety of ultra-macromolecule PDLLA |
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| Sun Jiao,Xue Miao,Li Yongming et al.Ninth people's hospital,Shanghai Second Medical University,Shanghai Biomaterials Research and Test Center,Shanghai.Evaluation on biological safety of ultra-macromolecule PDLLA[J].Chinese Journal of Dental Materials and Devices,2000,9(4):195-197,209. |
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| Authors: | Sun Jiao Xue Miao Li Yongming Ninth people's hospital Shanghai Second Medical University Shanghai Biomaterials Research and Test Center Shanghai |
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| Institution: | Sun Jiao,Xue Miao,Li Yongming et al.Ninth people's hospital,Shanghai Second Medical University,Shanghai Biomaterials Research and Test Center,Shanghai,200011 |
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| Abstract: | Objective To evaluate the biological safety for a new kind of ultra macromolecule PDLLA. Methods According to ISO 10993 documents, the cytotoxicity test, acute systemic toxicity test, sensitization test, haemolysis test and Ames test were investigated. Results There were no cytotoxicity, no acute systemic toxicity, no sensitivity, almost no obvious heamolysis, and no mutagenicity in Ames test. Conclusion There was a good biocompatibility for this kind of ultra macromolecule PDLLA material. |
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| Keywords: | Ultra macromolecule PDLLA Biological safT |
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