| GAS/CCK-2R及其拮抗剂在胰腺癌治疗中的作用 |
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| 引用本文： | 陈卫波,吴俊华,江春平.GAS/CCK-2R及其拮抗剂在胰腺癌治疗中的作用[J].国际外科学杂志,2010,37(9). |
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| 作者姓名： | 陈卫波 吴俊华 江春平 |
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| 作者单位： | 1. 南京大学医学院,南京,210093
2. 南京大学医学院附属鼓楼医院肝胆外科,南京,210093 |
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| 基金项目： | 南京市卫生局重点基金 |
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| 摘 要： | 近年来发现胃泌素/胆囊收缩素-2受体(gastrin/cholecystokinin-2 receptors,GAS/CCK-2R)与胰腺癌的发生、发展有密切关系.它在人体内广泛分布,但不存在于正常胰腺外分泌部.CCK-2R在胰腺癌组织中出现异常表达,该表达引起了胰腺外分泌部蛋白的异常表达和激活,导致腺泡细胞形态学和表型的变化,并使胰腺对致癌物质的敏感性增加.一些GAS/CCK-2R拮抗剂可用于胰腺癌的早期和晚期治疗.
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| 关 键 词： | 胰腺癌 拮抗剂 |
GAS/CCK-2R and function of its antagonists in treatment of the pancreatic cancer |
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| CHEN Wei-bo,WU Jun-hua,JIANG Chun-ping.GAS/CCK-2R and function of its antagonists in treatment of the pancreatic cancer[J].International Journal of Surgery,2010,37(9). |
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| Authors: | CHEN Wei-bo WU Jun-hua JIANG Chun-ping |
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| Abstract: | Studies in recent years revel that there is a close relationship between gastrin/cholecystokinin-2 receptors (GAS/CCK-2R) and pancreatic cancer. CCK-2R is widely distributed in human body, but not in normal exocrine pancreas. However, CCK-2R is abnormally expressed in pancreatic carcinoma. The abnormal expression of CCK-2R in pancreatic tissues leads to the abnormal protein expression and activation, changes in acinar cells' morphology and phenotype and an increase in the sensitivity to carcinogenic substances. And some GAS/CCK-2R antagonists can be used for the early and late treatment of pancreatic cancer. |
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| Keywords: | GAS/CCK-2R |
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