小剂量他达拉非治疗保留性神经的前列腺癌根治术后勃起功能障碍的探讨

目的：探讨小剂量他达拉非治疗保留性神经的前列腺癌根治术后勃起功能障碍的疗效和安全性。方法：回顾性分析72例保留神经的前列腺癌根治术后患者的临床资料，72例患者分为治疗组37例，每日服用他达拉非5mg 1次；观察组35例，不服药。分别在术前、术后6个月和1年，采用国际勃起功能指数-5对患者进行调查。结果：在术后6个月，治疗组和观察组的IIEF-5总分分别为（9.7±3.2）分和（6.7±3.5）分；在术后1年中，治疗组的IIEF-5总评分为（12.8±6.6）分，显著高于观察组（7.8±2.9）分，差别有统计学意义（P＜0.05）。他达拉非的副作用有面部潮红4例（10.8％）、头痛2例（5.4％）和头晕1例（2.7％）。结论：保留性神经的前列腺癌根治术后，患者每日口服他达拉非5 mg 1次，耐受性良好，与对照组相比，可以起到明显改善勃起功能障碍的效果。

Low dose tadalafil in the treatment of erectile dysfunction after nerves sparing radical prostatectomy

Objectives：To study the efficacy and safety of low doses tadalafil in the treatment of erectile dysfunction after nerves sparing radical prostatectomy.Method：The clinical data of 72 patients receiving nerves sparing radical prostatectomy was analyzed retrospectively.The 72 patients were classified into the tadalafil group （n=37）and the non-tadalafil group （n=35）.Patients in tadalafil group took 5mg tadalafil once a day and patients in non-tadalafil group took nothing.The International Index of Erectile Function （IIEF-5 ）was used to analyze the clinical data of the two groups before the surgery,6 months and 1 year after surgery.Results：6 months after surger-y,the total IIEF-5 scores of the tadalafil group and the non-tadalafil group were 9.7±3.2 and 6.7±3.5,respective-ly.1 year after surgery,the total IIEF-5 score in the tadalafil group was significantly greater than that in the non-tadalafil group （1 2.8±6.6 vs.7.8±2.9,P〈0.05）.The reported side effects were 4 cases of flushing （1 0.8%）,2 cases of headache （5.4%）and 1 case of dizziness （2.7%）.Conclusion：In ED patients after nerves sparing radical prostatectomy,a once-daily dose of tadalafil 5mg is well tolerated and can significantly improve the situation of erec-tile dysfunction.