妊娠期梅毒患者妊娠结局及其影响因素分析研究

目的：研究观察妊娠期梅毒患者妊娠结局及其影响因素。方法：选取2009年1月至2014年3月本院收治的35例妊娠期梅毒患者为观察组，并以同期的35例健康孕产妇为对照组，然后将两组的妊娠结局及新生儿情况进行统计及比较，同时比较观察组中不同治疗时间及TRUST滴度者的妊娠结局及新生儿情况。结果：观察组的足月分娩率显著低于对照组，早产率、死胎率和流产率均高于对照组，新生儿情况也明显差于对照组。同时观察组中治疗时间较晚及未接受治疗者TRUST滴度≥1：8，患者的妊娠结局及新生儿情况明显差于早期接受治疗及TRUST滴度〈1：8者，P均〈0．05，均有显著性差异。结论：妊娠期梅毒患者妊娠结局相对较差，且治疗时间及TRUST滴度对其最终的妊娠结局及新生儿情况均影响较大，应重视对妊娠期梅毒患者的早期治疗。

Pregnancy outcome of patients with syphilis and its influence factors

Objectives： To investigate the pregnancy outcome of patients with syphilis and its influence fac- tors. Methods： 35 pregnant patients with syphilis in our hospital from January 2009 to March 2014 were selected as observation group, 35 healthy pregnant women at the same time were selected as the control group. The pregnancy outcome and newborns situation of the two groups were analyzed and compared, and the pregnancy outcome and newborns situation of patients with different treatment time and TRUST titer in the observation group were compared too. Results： The full - term delivery rate of observation group was significantly lower than that of control group ; the premature delivery rate, stillbirth rate and abortion rate were all higher than those of control group; the newborns sit- uation were obviously worse than that of control group; the pregnancy outcome and newborns situation of observation group without treatment, with later treatment and TRUST titer ≥ 1：8 were all significantly worse than those of pa- tients with early treatment and TRUST titer 〈 1 ： 8, all P 〈 0. 05 without significant differences. Conclusion： The pregnancy outcome of patients with syphilis is relatively worse, and impact of treatment time and TRUST titer on the pregnancy outcome and newborns situation is great, so early treatment for pregnant patients with syphilis should be given more attention to.