在动态模拟体液中致密CaP陶瓷表面形貌对类骨磷灰石层形成的影响研究

磷酸钙陶瓷植入体内后其表面类骨磷灰石层的形成是诱导成骨的先决条件。本实验在模拟体液 (Simu-lated body fluid,SBF)以人体骨骼肌组织的正常生理流率 (2 ml/ 10 0 m l· min)下 ,研究在动态 SBF中致密磷酸钙陶瓷表面形貌对类骨磷灰石层形成的影响。结果表明 :在生理流速条件下 ,材料的粗糙表面有利于类骨磷灰石层的形成 ,加大 SBF中 Ca2 +、HPO4 2 -离子浓度 ,类骨磷灰石层的形成速度加快。本研究进一步证实了材料的几何形貌对类骨磷灰石形成的影响 ,加深了对磷酸钙陶瓷在体内诱导成骨机理的理解

The Effects of Surface Morphology of Calcium Phosphate Ceramics on Apatite Formation in Dynamic SBF

Bone like apatite formation on the surface of calcium phosphate ceramics has been believed to be the prerequisite of new bone growth on ceramics and to be related to the osteoinductivity of the material. The research of the factors effecting bone like apatite formation is a great help in understanding the mechanism of osteoinduction. This paper is aimed to a comparative study of in vitro formation of bone like apatite on the surface of dense and rough calcium phosphate ceramics with SBF flowing at different rates. The results showed that the rough surface was beneficial to the formation of bone like apatite, and the apatite formed faster in 1.5 SBF than in SBF. Rough surface, namely, larger surface area, increased the dissolution of Ca 2+ and HPO 4 2 and higher concentration of Ca 2+ and HPO 4 2 ions of SBF and was inturn advantageous to the accumulation of Ca 2+ ,HPO 4 2 ,PO 4 3 near the ceramic surface . Local supersaturating concentration of Ca 2+ ,HPO 4 2 ,PO 4 3 near sample surface was essential to nucleation of apatite on the surface of sample.