炎症因子与多囊卵巢综合征的关系

多囊卵巢综合征（PCOS）的发病机制十分复杂，包括遗传因素、环境因素、炎症因素等。近年来在PCOS中炎症因子与胰岛素抵抗（IR）、肥胖及下丘脑-垂体-性腺轴之间的相互关系是讨论的重点。炎症因子可直接或经由脂肪组织间接介导IR，脂肪组织可分泌多种细胞因子，PCOS患者细胞因子表达异常，促使炎症反应的发生，并参与IR过程。此外，炎症因子可能直接参与下丘脑-垂体-性腺轴功能紊乱，通过对性腺轴的直接作用，影响PCOS患者卵泡发育、成熟及排卵等过程。遗传因素方面，许多炎症因子基因多态性与PCOS发生、发展存在一定关联。

The Relationship between Inflammatory Cytokines and Polycystic Ovary Syndrome

The pathogenesis of PCOS is very complicated，including the genetic factors，environmental factors，inflammatory factors and so on. In recent years，the relationship between inflammatory factors，insulin resistance，obesity and the hypothalamic-pituitary-gonadal axis and its impact on the pathogenesis of polycystic ovary syndrome is the focus of discussion. Inflammatory cytokines could mediate insulin resistance via adipose tissue. Adipose tissue could secrete multiple cytokines. The abnormal expression of cytokines promotes inflammatory process and participates in the process of insulin resistance in PCOS patients. Besides, inflammatory cytokines may be directly involved in the dysfunction of the hypothalamic-pituitary-gonadal axis and result in the abnormal follicular development, maturation and ovulation process in PCOS patients. In genetic factors, there is a certain correlation between the gene polymorphism of inflammatory cytokines and PCOS.