Blood pressure and heart rate variability
in patients with essential hyperhidrosis |
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Authors: | J-M Senard M Simonetta-Moreau M-A Tran |
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Institution: | (1) Laboratoire de Pharmacologie, Medicale et Clinique INSERM U586 37 allees Jules Guesde, 31073 Toulouse cedex, France;(2) Federation de Neurologie, CHU Purpan, Toulouse, France |
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Abstract: | Introduction Essential
hyperhidrosis (EH) is often considered
to be related to an increased
activity of sympathetic nervous
system (SNS). However, there is a
lack of studies comparing autonomic
nervous system (ANS) activity
in controls and in EH patients.
The aim of the present study was to
simultaneously investigate in patients
with severe EH, blood pressure,
heart rate variability and
plasma catecholamine levels in
comparison with controls.Methods 19 EH patients and 20 controls with
normal ANS function assessed by
clinical testing were included.
Blood pressure (BP) and heart rate
(HR) were measured using a Finapres
beat-to-beat monitor. BP
and HR variabilities (Fast Fourier
transformation) and plasma catecholamine
levels (HPLC) were obtained
at rest and during a 15 min
70° head-up tilt test.Results At rest,
a significantly higher relative energy
of low frequency band (LF) of
systolic BP was observed in EH in
comparison with controls contrasting
with the lack of difference in
BP, HR, plasma catecholamine levels
and in other spectral parameters.
During tilt, all changes were
comparable in EH and in control
subjects excepting relative energy
of LF of SBP which remained unchanged
when compared to the
resting condition in EH group.Conclusions In EH, SNS is not overreactive
even if resting overactivity
cannot be excluded. |
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Keywords: | essential hyperhidrosis spectral variability catecholamines head-up tilt |
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