阿片肽对生长抑素镇痛和加强电针镇痛作用的影响

本工作以钾离子透入引起大鼠甩尾为痛指标，观察了内源性阿片肽与ＳＳ镇痛及加强电针镇痛作用的关系。侧脑室注射纳洛酮可部分阻断 ＳＳ的镇痛和增强电针镇痛的效应，说明 ＳＳ的镇痛和增强电针镇痛的作用可能与内源性阿片肽有关。侧脑室分别给予抗β－内啡肽血清（ＡＥＰＳ）、抗亮－脑啡肽血清（ ＡＬＥＫＳ）和抗强啡肽血清（ ＡＤＹＮＳ），观察到 ＡＥＰＳ和 ＡＬＥＫＳ可减弱ＳＳ的镇痛和增强电针镇痛的效应，其中 ＡＥＰＳ减弱 ＳＳ的镇痛作用较强， ＡＬＥＫＳ减弱 ＳＳ增强电针镇痛的作用较强，而 ＡＤＹＮＳ无论对 ＳＳ的镇痛作用还是增强电针镇痛的作用均无影响。以上结果表明 ＳＳ的镇痛和增强电针镇痛的作用与β－内啡肽和脑啡肽有关，而与强啡肽关系不大。

The Effect of Opiate Peptides on Somatostatin-induced Analgesia and Enhancing Electroacupuncture Analgesia

It was observed the effects of intracerebroventricular (i. c. v. ) injection of naloxone and anti- opi- oid peptide sera on the analgesia and the enhancement of electroacupuncture (EA ) analgesia caused by somatostatin (SS) in this study. Injection(i. c. v. ) of naloxone could block partly the analgesia and the enhancement of electroacupuncture(EA) analgesia caused by SS, which suggested that analgesia and the enhancement of EA analgesia caused by SS might be related to endogenous opiate peptides (EOP). After injection (i. c. v. ) of anti-beta-endorphin serum(AEPS), anti-fen-enkephalin serum(ALEKS), anti-dynorphin A1-13 serum(ADYNS) respectively, it was found that AEPS and ALEKS could reduce the effect of SS on analgesia and EA analgesia, but ADYNS failed to have any effect. AEPS could stronger reduce the effect of SS on analgesia but ALEKS has a stronger action to reduce the effect of SS on EA analgesia. Those results implied that the role of SS in analgesia and enhancing EA analgesia was related with beta-endorphin and enkephalin, but not dynorphin in the central nervous system.