肾虚型不孕症与gp130家族成员的相关性研究

目的探讨肾虚不孕症gp130家族成员的分泌峰值阶段其血清含量的变化，分析不孕症肾虚型与子宫内膜容受性的相关性。方法选择不明原因性不孕症患者90例，分为肾阴虚、肾阳虚和非肾虚组，对照组30例，分别于排卵后的第4,6和8天，用酶联免疫吸附法（ELISA）方法检测血清白血病抑制因子（HF）、白介素-6（IL-6）和白细胞介素-11（IL-11）的水平，用化学发光法检测排卵后第8天血清雌二醇（E2）和孕激素（PRG）水平。结果肾虚不孕患者排卵后第4天血清LIF水平明显低于对照组；排卵后第8天肾不孕症组血清PRG水平明显低于对照组，而血清E2水平明显高于对照组，以肾阳虚组最高；不孕患者血清LIF与PRG水平呈正相关（r=0．3）；LIF、E2和年龄与肾虚不孕症存在相关性，LIF为肾虚不孕症的保护因素（ORLIF=0．015），E2和年龄为肾虚不孕症的促进因素（ORE2=1．009和OR年龄=1．261）。结论分泌峰值日血清LIF水平下降和E2水平上升，为肾虚不孕症的微观指标变化之一，患者的年龄是促进肾虚不孕症发生的重要因素。子宫内膜容受性下降为肾虚不孕症的发病机制之一。

Research on relationship between infertility of kideny-deficiency syndrome type and protein express of GP130 cytokines family

[Objective] Through investigating the serum peak level changes of gp130 family in patients with kidney-deficiency syndrome types of infertility, analysis the relationship between kidney-deficiency infertility and endometrial receptivity. [Methods] 90 cases of unintelligible infertility were included, all the patients with infertility were divided into 3 groups (kidney yin deficiency group, kidney yang deficiency group, non kidney deficiency group). 30 cases of return visiting patients who have had medical a...