| 拟青霉代谢物提取物对慢性应激抑郁模型大鼠皮质激素受体mRNA表达的影响 |
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| 引用本文： | 阚红卫,明亮,郑丽芳,尹艳艳. 拟青霉代谢物提取物对慢性应激抑郁模型大鼠皮质激素受体mRNA表达的影响[J]. 中国药房, 2006, 17(3): 177-179 |
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| 作者姓名： | 阚红卫 明亮 郑丽芳 尹艳艳 |
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| 作者单位： | 安徽医科大学药理教研室,合肥市,230032 |
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| 基金项目： | 安徽省科技厅科研项目;安徽省教育厅科研项目 |
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| 摘 要： | 目的研究拟青霉代谢物提取物(BCPT)对慢性不可预见性应激(CUS)抑郁模型大鼠海马和皮质中盐皮质激素受体(MR)、糖皮质激素受体(GR)mRNA表达的影响。方法采用CUS法建立大鼠抑郁模型,用逆转录-聚合酶链反应方法分别检测CUS模型大鼠海马和皮质中MR、GR mRNA的表达。结果BCPT可上调CUS模型大鼠皮质和海马中MR、GR mRNA的表达,降低MR/GR mRNA值。结论BCPT的抗抑郁作用可能与上述结果有关。
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| 关 键 词： | 慢性应激 糖皮质激素受体 盐皮质激素受体 mRNA 表达 |
| 文章编号： | 1001-0408(2006)03-0177-03 |
| 收稿时间： | 2005-07-20 |
| 修稿时间： | 2005-09-05 |
Effect of BCPT on Expression of Hippocampus and Cortex MR,GR mRNA in CUS Rats |
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| KAN Hongwei,MING Liang,ZHENG Lifang,YIN Yanyan. Effect of BCPT on Expression of Hippocampus and Cortex MR,GR mRNA in CUS Rats[J]. China Pharmacy, 2006, 17(3): 177-179 |
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| Authors: | KAN Hongwei MING Liang ZHENG Lifang YIN Yanyan |
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| Affiliation: | Dept of Pharmacology, Anhui Medical University, Hefei, 230032 |
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| Abstract: | OBJECTIVE:To explore the antidepressant effects of bioactive compounds from paecilomyces tenuipes(BCPT)on expression of hippocampus and cortex mineralocorticoid receptor(MR),glucocorticoid receptor(GR)mRNA in CUS(chronic unpredictable stress)rats.METHODS:The depression model rat was produced by CUS,the therapy effect of BCPT was observed in CUS rats.It detected expression of hippocampus and cortex MR,GR mRNA with RT-PCR in CUS rats.RESULTS:BCPT could enhance the expression of hippocampus and cortex MR,GR mRNA or decrease the ratio of MR/GR mRNA in CUS rats.CONCLUSION:BCPT could obviously enhance the expression of hippocampus and cortex MR,GR mRNA or decrease the ratio of MR/GR mRNA in CUS rats,the result of this study suggested that BCPT possess certain antidepressant effect. |
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| Keywords: | mRNA |
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