Estimation of in vivo and in vitro exposure to bisphenol A as food contaminant |
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Affiliation: | 1. From the Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.;2. the Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.;3. the School of Public Health and Management, Chongqing Medical University, Chongqing, China.;4. The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.;5. the School of Public Health and Management, Chongqing Medical University, Chongqing, China.;4. Center of Biofuels and Bioproducts, Instituto Tecnológico Agrario de Castilla y León (ITACyL), León, Spain |
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Abstract: | The goal of this cross-sectional study was to examine the occurrence of bisphenol A (BPA) in the morning spot urine taken from 145 female volunteers of various ages. Total urine BPA concentration was detected in 38.6% samples in the 0.92–70.96 μg/g Cr range. The majority of BPA + women belonged to the 25 + body mass index (BMI) group (54.5% were overweight and 43.4% were obese women). Occurrence of BPA in the urine samples was higher at 40 + ages. The maximum BPA concentration of 70.96 μg/g Cr was detected in the urine sample of an obese woman. It is known that BPA is highly toxic in vitro. In this study BPA impaired significantly the growth of all investigated cell lines, i.e. the EC50 values were reached at very low concentrations, in the range from 3.24 to 34.85 μg/mL. The obtained in vivo results suggest that a higher exposure to BPA could contribute to weight problems in women and the absence of the BPA in vitro selective toxicity studies indicates to its general toxic mode of action and raises awareness of the health risks associated with its ubiquitous presence in the environment. |
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Keywords: | Bisphenol A Endocrine disrupting compounds Obesity Toxicity Urine BMI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" body mass index BPA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" bisphenol A BSTFA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" N,O-Bis(trimethylsilyl)trifluoroacetamide Cr" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" creatinine DMEM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" Dulbecco's modified eagles medium DMSO" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" dimethyl sulphoxide half maximal effective concentration EDCs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" endocrine disrupting compounds EDTA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" ethylenediaminetetraacetic acid EI+" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" positive electron ionization FCS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" fetal calf serum GC–MS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" gas chromatography coupled to mass spectrometric detection H-4-II-E" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" rat hepatocarcinoma cell line HeLa" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" cervix epitheloid carcinoma cell line HT-29" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" colon adenocarcinoma cell line MCF7" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" breast adenocarcinoma cell line MRC-5" },{" #name" :" keyword" ," $" :{" id" :" kwrd0200" }," $$" :[{" #name" :" text" ," _" :" human fetal lung cell line MTBE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0210" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" methyl " },{" #name" :" italic" ," _" :" tert" },{" #name" :" __text__" ," _" :" -butyl ether NOAEL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0220" }," $$" :[{" #name" :" text" ," _" :" no observed adverse effect level PP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0230" }," $$" :[{" #name" :" text" ," _" :" polypropylene SIM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0240" }," $$" :[{" #name" :" text" ," _" :" selective ion monitoring SRB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0250" }," $$" :[{" #name" :" text" ," _" :" sulphorhodamine B |
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