Evaluation of the in vivo genotoxicity of Allura Red AC (Food Red No. 40) |
| |
| Affiliation: | 1. Departamento de Química, ICEx, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil;2. Instituto Nacional de Ciência e TecnologiaemBioanalítica (INCT Bio), 13083-970, Campinas, SP, Brazil;1. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;2. Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran;3. Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran;4. Department of Organic Colorants, Institute for Color Science and Technology, 1668814811 Tehran, Iran;5. Center of Excellence for Color Science and Technology, Institute for Color Science and Technology, 16656118481 Tehran, Iran;6. Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran;1. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russian Federation;2. Irkutsk State Technical University, 664074 Irkutsk, Russian Federation |
| |
| Abstract: | Allura Red AC (Food Red No. 40) is a red azo dye that is used for food coloring in beverage and confectionary products. However, its genotoxic properties remain controversial. To clarify the in vivo genotoxicity, we treated mice with Allura Red AC and investigated the induction of DNA damage (liver, glandular stomach), clastogenicity/anuegenicity (bone marrow), and mutagenicity (liver, glandular stomach) using Comet assays, micronucleus tests, and transgenic gene mutation assays, respectively. All studies were conducted in accordance with the Organization for Economic Co-operation and Development (OECD) guideline. Although Allura Red AC was administered up to the maximum doses recommended by the OECD guideline, no genotoxic effect was observed in any of the genotoxic endpoints. These data clearly show no evidence of in vivo genotoxic potential of Allura Red AC administered up to the maximum doses in mice. |
| |
| Keywords: | Allura Red AC (Food Red No. 40) Comet assay Micronucleus test Transgenic gene mutation assay OECD guidelines |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
