Comparative effects of valsartan plus cilnidipine or hydrochlorothiazide on nocturnal home blood pressure |
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Authors: | Takeshi Fujiwara Satoshi Hoshide Naoko Tomitani Hiroshi Kanegae Kazuomi Kario |
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Affiliation: | 1. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke Japan ; 2. Genkiplaza Medical Center for Health Care, Tokyo Japan |
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Abstract: | We tested our hypothesis that, in hypertensive patients with higher nocturnal home systolic blood pressure (HSBP) at baseline, a valsartan/cilnidipine (80/10 mg) combination would reduce nocturnal HSBP more markedly than a valsartan/hydrochlorothiazide (80/12.5 mg) combination. Patients measured their nocturnal HSBP over three nights prior to study randomization and at the end of treatment. Sixty‐three and 66 patients comprised the valsartan/cilnidipine and valsartan/hydrochlorothiazide groups; their respective baseline nocturnal HSBP values were 124.3 ± 15.6 and 125.8 ± 15.2 mm Hg (P = .597). Nocturnal HSBPs were significantly reduced from baseline in both groups. Although the valsartan/hydrochlorothiazide group exhibited a significantly greater reduction in nocturnal HSBP compared to the valsartan/cilnidipine group (−5.0 vs. −10.0 mm Hg, P = .035), interaction between the treatment groups and the baseline nocturnal HSBP levels for the changes in nocturnal HSBP after the treatment periods was significant (P = .047). The BP‐lowering effect of valsartan/cilnidipine was more dependent on baseline nocturnal HSBP than that of valsartan/hydrochlorothiazide. |
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Keywords: | automatic ICT‐ based home blood pressure monitoring device, morning blood pressure, nocturnal home blood pressure, valsartan/cilnidipine combination, valsartan/hydrochlorothiazide combination |
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