吸烟与口腔鳞癌发病相关性的病例对照研究

目的：探讨吸烟与口腔鳞癌发病之间的关系。方法：对病例组74例口腔鳞癌患者和对照组131例腮腺多形性腺瘤患者的吸烟史进行调查分析，对所得数据进行X^2检验，并计算优势比（OR）及其95％可信限，为排除性别和年龄这两个可能的混杂因素的影响，也对男性患者和45岁以上患者吸烟史进行对比分析。结果：对照组吸烟率为22．1％，病例组吸烟率为58．1％，明显高于对照组（P＜0．005），OR为4．9，其95％可信限为2．7－8．9；在男性患者和45岁以上患者中，病例组吸烟率均显著大于对照组（P＜0．005）。结论：吸烟是口腔鳞癌发病的危险因素之一。

A case-control study on an association between smoking and oral squamous cell carcinoma

Objectives: To further examine a preliminary association between smoking and the subsequent development of oral squamous cell carcinoma. Methods:Seventy-four consecut ive patients with oral squamous cell c arcinoma served as cases and 131 conse cutive patients with pleomorphic adenomas of the parotid gland served as controls. A smoking history of every patient was obtained, and calculation of an odds ratio (OR) was carried out. In order to exclude sex and age a s possible confounders, the odds ratio was recalculated. Results:In the entire study population, there were 4 3 smokers and 31 nonsmokers in the cases and 29 smokers and 102 nonsm okers in the controls. An odds ratio of 4.9 was determined in favor o f the association between smoking and oral squamous carcinoma ( P <0.005). In males only, there were 35 smokers and 11 nonsmokers in the cases and 20 smokers and 38 nonsmokers in the controls, with an odds ratio of 6.0 ( P <0.005). In the patients over 45 years of age, there were 34 smokers and 15 nonsmokers in the cases an d 17 smokers and 40 nonsmokers in the controls, with an odds ratio of 5.3 ( P <0.005). Conclusions:Smoking m ay be one of the etiologic factors associated with oral squamous cell carcin oma.