冠状动脉粥样硬化性心脏病患者血清尿酸特点分析

目的分析冠状动脉粥样硬化性心脏病（冠心病）患者血清尿酸浓度的特点,探讨检测血清尿酸浓度在预防冠心病发生中的作用。方法选取2010年3月至2011年2月在广东省人民医院住院,怀疑冠心病的患者430例为研究对象。首先根据造影结果分为冠心病组316例,对照组114例,测定两组的血清尿酸浓度,并进行对比分析。然后,根据世界卫生组织高尿酸血症诊断标准,将患者分成高尿酸血症组和非高尿酸血症组,比较两组的冠心病患病率。最后,患者按血清尿酸浓度分为4个浓度组,比较4组冠心病的患病率。结果冠心病组血尿酸浓度高于对照组,差异有统计学意义[（374.42±98.54）μmol.L-1vs.（374.42±98.54）μmol.L-1,P〈0.05]。高尿酸组中冠心病患病率高于非高尿酸组,但差异无统计学意义（P=0.217）。不同血清尿酸浓度的4组中,血清尿酸浓度越高,冠心病患病率也越高,与浓度最低组比较,差异有统计学意义（P=0.001）。结论血清尿酸浓度可能是冠心病的危险因素之一,血清尿酸浓度高者患冠心病的可能性较大;加强血清尿酸浓度检测对预防冠心病的发生具有重要意义。

Characteristic of serum uric acid in patients with coronary heart disease

Objectives To study characteristic of serum uric acid in patients with coronary heart disease(CHD),and to approach the value of measuring serum concentration of uric acid in CHD prevention.Methods Totally 430 patients with suspected CHD in Guangdong General Hospital from March 2010 to February 2011 were included in this study.Firstly,according to the results of the coronary artery angiography(CAG),the patients were divided into two groups:316 patients in CHD group and 114 patients in control group.Serum concentrations of the uric acid were measured and compared between the 2 groups.Secondly,according to diagnostic criteria of hyperuricemia from World Health Organization,the patients were divided into high serum concentration of uric acid group and non-high serum concentration of uric acid group.Case rates of CHD between the 2 groups were compared.Thirdly,according to serum concentration of uric acid,all patients were divided into 4 different serum concentration of uric acid groups,and cases rate among the 4 group were compared.Results Serum concentration of uric acid in CHD group were siginificantly higher than that in control group [(374.42±98.54) μmol·L-1 vs.(374.42±98.54)μmol·L-1,P<0.05].Case rate of high serum concentration of uric acid group was higher than that of non-high serum concentration uric acid,but there was no statistical significance(P=0.217).The higher the serum concentration of uric acid the group was,the higher case rate of the group was.Case rates of the 3 high serum concentration of uric acid groups were siginificantly higher than that of the lowest serum concentration of uric acid group(P=0.001).Conclusions Serum concentration of uric acid may be one of the risk factor of CHD.The higher serum concentration of uric acid the patient is,the more likely he will suffer from CHD.Measuring serum concentration of uric acid has important meaning for CHD prevention.