| 类风关巴布剂体外透皮吸收研究 |
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| 引用本文： | 陈凌云,张卫兵,张丽萍. 类风关巴布剂体外透皮吸收研究[J]. 医药导报, 2004, 23(7): 0445-0446 |
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| 作者姓名： | 陈凌云 张卫兵 张丽萍 |
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| 作者单位： | 1. 浙江省温州市药品检验所,325028
2. 浙江省温州医学院附属第一医院药剂科,325000 |
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| 基金项目： | 浙江省中医药科研项目 (项目编号 :2 0 0 0C83 ) |
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| 摘 要： | 目的：探讨类风关巴布剂透皮吸收的效果。方法：采用改良Franz扩散池法，研究了类风关涂膜剂及其新剂型类风关巴布剂中的雷公藤甲素的透皮吸收特点，用高效液相色谱法(HPLC)检测透过的雷公藤甲素。结果：巴布剂中雷公藤甲素的透皮吸收符合Higuchi方程，即Q与t1/2呈线性关系；涂膜剂的体外透皮是零级过程，4～12 h内透皮吸收接近恒速。结论：巴布剂较涂膜剂有较好的缓释效果。
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| 关 键 词： | 类风关巴布剂 类风关涂膜剂 雷公藤甲素 透皮吸收 |
| 文章编号： | 1004-0781(2004)07-0444-02 |
| 修稿时间： | 2004-02-16 |
Experimental Study on Transdermal Delivery of Rhemeutoid-Arthrosis Babugao |
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| CHEN Ling-yun ,ZHANG Wei-bing ,ZHANG Li-ping. Experimental Study on Transdermal Delivery of Rhemeutoid-Arthrosis Babugao[J]. Herald of Medicine, 2004, 23(7): 0445-0446 |
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| Authors: | CHEN Ling-yun ZHANG Wei-bing ZHANG Li-ping |
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| Affiliation: | CHEN Ling-yun 1,ZHANG Wei-bing 2,ZHANG Li-ping 1 |
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| Abstract: | Objective:To explore the transdermal delivery of rhemeutoid-arthrosis babugao. Methods:The improved Franz diffusing cells were used to study transdermal delivery of triptolide in rhemeutoid-arthrosis babugao and in rhemeutoid-arthrosis liniment. The content of permeated triptolide was determined by HPLC. Results:The transdermal delivery of triptolide in rhemeutoid-arthrosis babugao was in accordance with Higuchi equation. And that of liniment was in accordance with zero-grade releasing equation. Conclusion:Rhemeutoid-arthrosis babugao is better than rhemeutoid-arthrosis liniment in sustained-release. |
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| Keywords: | Rhemeutoid-arthrosis babugao Rhemeutoid-arthrosis liniment Triptolide Transdermal delivery |
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