砷冶炼厂工人皮肤损害与尿中砷甲基化产物的关系

目的探讨职业砷接触致皮肤病发生与尿中砷甲基化产物的关系。方法选择偏远山区冶炼厂为研究现场,暴露组为91名工人,对照组58人。监测作业场所工作岗位中砷化合物浓度,进行健康监护体检和尿砷形态分析,计算3种砷化合物百分率及一、二级甲基化指数。结果冶炼厂所有检测岗位砷化合物浓度均超过国家职业卫生标准,91名工人中36人存在明显慢性砷中毒样皮肤损害,尿中3种砷化合物(无机砷、甲基砷酸、二甲基砷酸)浓度(Log10)分别为(2.18±0.40)、(2.26±0.35)和(2.77±0.31)μg/g肌酐,明显示高于接砷但无皮肤损害的工人及对照组工人,差异均有统计学意义,冶炼厂存在皮肤损害的工人尿中甲基砷酸浓度占总砷百分率和二级甲基化指数均明显高于其他工人。结论尿中甲基化产物在冶炼厂工人皮肤损害中具有重要作用,二级甲基化指数与砷致皮肤损害有关。

Association between skin lesions and arsenic methylation product in urine of workers from arsenic smelting plant

[Objective]To study the relationship between skim lesions and metabolites of arsenic in urine of workers exposed occupationally to arsenic.[Methods]The smelting plants which were in outlying mountain area were selected as study object.A total of 91 arsenic exposed workers were recruited,and 58 other workers as control group.Arsenic compounds concentration in operating posts of working space were detected,physical examination was performed,and morphological analysis of arsenic in urine was done.At the same,percentages of 3 arsenic compounds,primary and second methylation indexes were calculated.[Results] Arsenic concentrations of all operating posts were over national occupational health standards.There were 36 workers who had obvious skin lesions of chronic arsenic toxicosis.The concentrations of inorganic arsenic,methyl arsenate and dimethyl arsenate(Log10) were(2.18 ±0.40)μg/g,(2.26±0.35)μg/g and(2.77±0.31)μg/g creatinine which were significantly higher than those of the workers without skin lesions and from the control group.Percentage of urine concentration of methyl arsenate in total arsenic and secondary methylation index of workers with skin lesions were significantly higher than those of other workers in smelting plant.[Conclusion]Methylated products in urine play an important role in skin lesions of smelter workers,secondary methylation index is associated with arsenic induced skin damage.