非糖尿病冠心病患者糖化血红蛋白与冠脉病变相关性分析

目的探讨非糖尿病冠心病患者糖化血红蛋白（HbA1C）水平与冠状动脉病变的相关性。方法选择经冠脉造影明确诊断冠心病的非糖尿病患者290例,按照HbA1C水平以三分位法分为低水平组（115例,HbA1C≤5.6mmol/L）,中水平组（91例,HbA1C：5.7-5.9mmol/L）,高水平组（84例,HbA1C≥6.0mmol/L）。冠状动脉造影结果使用Gensini评分。结果 HbA1C高水平组Gensini评分大于中水平组,中水平组Gensini评分大于低水平组,但无统计学意义。经Spearman偏等级相关分析,校正年龄、性别、吸烟状况、饮酒状况、心梗史、病变支数、空腹血糖、尿酸、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、高敏C反应蛋白、BMI（体重指数）等因素后,HbA1C水平与Gensini评分无显著关系。结论在非糖尿病的冠心病人群中,HbA1C水平与冠脉狭窄程度无明显相关性。

The relation of glycosylated hemoglobin level with coronary lesion in non-diabetic coronary heart disease individuals

Objective To examine the relation between HbA1C level and coronary lesion in non-diabetic coronary heart disease individuals.Methods 290 nondiabetic inpatients who diagnosised CHD by coronary angiography were enrolled with glycosylated hemoglobin level to low level group(n=115,HbA1C≤5.6mmol/L),middle level group(n=91,HbA1C:5.7-5.9mmol/L),high level group(n=84,HbA1C≥6.0mmol/L).The consequences of coronary angiography were judged by Gensini score.Results The Gensini score of high level group greater than middle level group,The Gensini score of middle level group greater than low level group,but did not receive principle of statistics significance.After adjusted the potential risk factors such as age、sex、smoking、drinking、the history of myocardial infarction、coronary artery lesion branch、fasting serum glucose、UA、TG、TC、HDL-C、LDL-C、HSCRP、BMI with Spearman partial correlation test,HbA1C level had no conspicuous relationship with Gensini score.Conclusions HbA1C has no obviously correlation with coronary stenosis degree in non—diabetic CHD individuals.