雄激素受体、基质金属蛋白酶-2在脑膜瘤中的表达及其临床意义

摘要] 目的 观察33例脑膜瘤患者肿瘤组织中雄激素受体（AR）、基质金属蛋白酶-2（MMP-2）的表达,研究与探讨AR、MMP-2的表达与脑膜瘤临床病理的相关性,以及AR、MMP-2表达与脑膜瘤的复发、恶性转化等生物学行为的相关性，为临床预测脑膜瘤的复发及指导术后治疗提供部分理论与实验依据。方法 应用免疫组化SP法检测33例脑膜瘤组织标本中的AR、MMP-2蛋白相关的表达情况。结果 １．在恶性脑膜瘤组中AR与MMP-2蛋白的表达明显高于良性组蛋白的表达。2．在良性复发脑膜瘤组MMP-2蛋白的表达明显高于良性未复发组的蛋白表达。3. AR蛋白与MMP-2蛋白在脑膜瘤中的表达具有相关性。结论 １．在恶性脑膜瘤组织中AR与MMP-2蛋白的表达明显高于良性脑膜瘤组织中的蛋白表达。2．在复发的良性脑膜瘤组织中MMP-2蛋白有较高的表达，明显高于良性未复发组脑膜瘤的蛋白表达。3.AR与MMP-2蛋白在脑膜瘤组织中的表达与其生物学行为有一定的关联，可作为鉴别脑膜瘤良、恶性诊断时有用的辅助诊断指标。MMP-2蛋白在良性脑膜瘤中较高的表达可能与脑膜瘤复发相关，MMP-2蛋白表达的检测对预测脑膜瘤的复发有一定意义。

The protein expression of AR and MMP-2 in meningioma and clinical significance

ABSTRACT Objectives This study was to investigate whether AR and MMP-2 present in meningioma, what the correlation between their expression with the clinical pathology tissue grading, and what the clinical significance of their expression level in evaluating meningioma in clinical pathology and predicting the prognosis after surgery. Methods 33 samples from different patients were collected. Each sample was undertaken Immunohistochemistry (IHC) staining. Results 1.The expressions of MMP-2 and AR protein in malignant group was higher significantly than that in the benign group. 2.The expressions of MMP-2 protein in recurrent benign group was higher significantly than that in the non-recurrent benign group. 3.There are relation between the expressions of MMP-2 and AR protein in meningiomas .Conclusions 1. The expressions of MMP-2 and AR protein in tissues of malignant meningiomas was higher significantly than that in the benign tissues.2. The expressions of MMP-2 protein in tissues of recurrent benign group was higher significantly than that in the tissues of non-recurrent benign. There was significant difference in these two groups.3. The expressions of MMP-2 and AR protein in tissues of meningiomas were related with the biological behavior of meningiomas.The expressions of MMP-2 and AR between benign meningiomas and malignant meningiomas may help clinical differential diagnosis. The high expression of MMP-2 protein in benign meningiomas was probably related with their recurrence. The expression of MMP-2 would be some significance to predict there currence of meningioma.