老年脑梗死患者红细胞分布宽度与动脉硬化相关性研究

目的 探讨老年脑梗死患者红细胞分布宽度（RDW）与脉搏波传导速度（PWV）之间的相关性.方法 对162例老年脑梗死住院患者进行横断面研究,按RDW四分位数将患者分为：最低四分位数组（A组）33例,低四分位数组（B组）39例,高四分位数组（C组）50例,最高四分位数组（D组）40例.收集临床一般资料及脑血管病危险因素,测定空腹血糖、血脂、糖化血红蛋白、肌酐、白细胞、血红蛋白、平均红细胞体积（MCV）、高敏C反应蛋白等,测量PWV.结果 从A组到D组,PWV逐渐增高,分别为1903.00±361.23、1961.62±445.98、2021.84±427.11、2175.73±492.99,D组较A组和B组差异有统计学意义（P＜0.05,P＜0.01）；相关分析显示,RDW与PWV（r =0.189,P＜0.05）、MCV（r =0.170,P＜0.05）呈正相关,与血红蛋白呈负相关（r=-0.214,＜0.01）；Logistic回归分析显示,RDW为PWV的危险因素（OR=3.549,95％ CI：61.394 ～216.107;P ＜0.01）.结论 老年脑梗死患者的RDW与PWV相关,RDW增高患者动脉硬化程度增加.

Association between red blood cell distribution width and pulse wave velocity in elderly inpatients with cerebral infarction

Objective To investigate the association between red blood cell distribution width （RDW）and pulse wave velocity（PWV）in elderly inpatients with cerebral infarction.Methods A total of 162 elderly inpatients with cerebral infarction were included in this cross-sectional study.Patients were categorized according to quartiles of RDW into four groups：the lowest RDW quartile group（A group,n =33）,low RDW quartile group（B group,n =39） high RDW quartile group （C group,n =50）,the highest RDW quartile group （D Group,n =40）,whose clinical date and risk factors of cardiovascular diseases （CVD） were collected,fasting glucose,serum lipid,hemoglobin A1c,createnine,white blood cell,hemoglobin,mean corpuscula volume as well as high-sensitivity C-reactive protein were measured.PWV was measured.Results There were graded increases in the level of PWV （1903.00 ± 361.23,1961.62 ± 445.98,2021.84 ± 427.11,2175.73 ± 492.99）,PWV were graded increases in group D than group A and group B （P ＜ 0.05,P ＜ 0.01）.There was a positive correlation between RDW and PWV （r =0.189,P ＜ 0.05）,MCV（r =0.170,P ＜ 0.05） and a negative correlation between RDW and Hb （r =-0.214,P ＜ 0.01）.After adjusting for other traditional arteriosclerosis risk factors RDW was risk factor for PWV （OR =3.549,95％ CI：61.394-216.107,P ＜ 0.01）.Conclusions Among elderly inpatients with cerebral infarction,RDW is related to PWV.Patients with increased RDW arterial stiffness increases.