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| 中药复方多成分体系群体药物动力学: 总量统计矩数学模型及参数计算研究 | |
| 引用本文： | 贺福元,邓凯文,刘文龙,石继连,杨岩涛.中药复方多成分体系群体药物动力学: 总量统计矩数学模型及参数计算研究[J].中国中药杂志,2011,36(20):2866-2870. |
| 作者姓名： | 贺福元 邓凯文 刘文龙 石继连 杨岩涛 |
| 作者单位： | 1. 湖南中医药大学药学院,湖南长沙410208;中药药性与药效国家中医药管理局重点实验室,湖南长沙410208;湖南中医药大学现代中药制剂制备技术与评价实验室,湖南长沙410208 2. 湖南中医药大学第一附属医院,湖南长沙,410007 3. 湖南中医药大学药学院,湖南长沙410208;中药药性与药效国家中医药管理局重点实验室,湖南长沙410208 4. 湖南中医药大学药学院,湖南长沙410208;湖南中医药大学现代中药制剂制备技术与评价实验室,湖南长沙410208 |
| 基金项目： | 国家自然科学基金项目(81073142,81173558);湖南省自然基金重点项目(11JJ2055) |
| 摘 要： | 目的:分析单成分群体药物动力学参数的计算方法,建立中药复方多成分体系的群体药物动力学:总量统计矩数参数测算方法.方法:针对单成分群体药物动力学分析原理,运用统计矩原理阐明并建立中药复方多成分体系药动学总量统计矩参数群体模型及参数计算方法.结果:建立了包括总量零阶矩(AUCT),一阶矩(MRTT),二阶矩(VCRT),总清除率( CLT),总表观体积(VT),总95％成分代谢时间区间,总95％成分累积代谢时间区间等中药复方群体药动学参数数学模型,并关联了单个成分群体药物动力学参数.结论:中药复方多成分体系的群体药物动力学数学模型及参数体系可在单成分群体药物动力学数学模型及参数体系基础上按总量统计矩原理建立；在群体典型值处依泰勒展开可获得总量统计矩参数群体典型、固定效应、生物间变异及实验误差. |
| 关 键 词： | 中药复方 多成分体系 群体药物动力学 总量统计矩 数学模型 参数分析 |
| 收稿时间： | 9/5/2011 12:00:00 AM |
Study of population pharmacokinetic model and parameter analyses for multiple components in Chinese matria medica formula |
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| HE Fuyuan,DENG Kaiwen,LIU Wenglong,SHI Jilian and YANG Yantao.Study of population pharmacokinetic model and parameter analyses for multiple components in Chinese matria medica formula[J].China Journal of Chinese Materia Medica,2011,36(20):2866-2870. | |
| Authors: | HE Fuyuan DENG Kaiwen LIU Wenglong SHI Jilian and YANG Yantao |
| Institution: | Department of Pharmaceutics, Hunan University of Chinese Medicine, Changsha 410208, China;Property and Pharmacodaynamic Key LSaboratory of Chinese Matria Medica, State Administration of Chinese Medicine, Changsha 410208, China;Pharmaceutical Preparation Technology and Evaluation Laboratory of Chinese Matria Medica, Hunan University of Chinese Medicine, Changsha 410208;The First Affinity Hospital, Hunan University of Chinese Medicine, Changsha 410007, China;Department of Pharmaceutics, Hunan University of Chinese Medicine, Changsha 410208, China;Property and Pharmacodaynamic Key LSaboratory of Chinese Matria Medica, State Administration of Chinese Medicine, Changsha 410208, China;Pharmaceutical Preparation Technology and Evaluation Laboratory of Chinese Matria Medica, Hunan University of Chinese Medicine, Changsha 410208;Department of Pharmaceutics, Hunan University of Chinese Medicine, Changsha 410208, China;Property and Pharmacodaynamic Key LSaboratory of Chinese Matria Medica, State Administration of Chinese Medicine, Changsha 410208, China;Department of Pharmaceutics, Hunan University of Chinese Medicine, Changsha 410208, China;Pharmaceutical Preparation Technology and Evaluation Laboratory of Chinese Matria Medica, Hunan University of Chinese Medicine, Changsha 410208 |
| Abstract: | Objective:To eluciate and establish a new population pharmacokinetic mathematical models and parameter calculation for the multiple components in the Chinese Matria Medica Formula(CMMF)through analyses of population pharmacokinetic parameter calculation for single compounds.Method:The model was been set up by statistic moment principle to form a new population pharmacokinetics for the mutiple components in CMMF according to the single compound population pharmacokinetic parameter calculation principle.Resul... |
| Keywords: | Chinese materia medica formulae mutiple component system population pharmacokinetics for CMMF total quantum statistical moment mathematical model parameter analyses |
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