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| 蜂蜜对阿昔洛韦在兔眼内转运动力学特性的影响 | |
| 引用本文： | 何群,王适,张湘晖,张健,姜宇,许江丽.蜂蜜对阿昔洛韦在兔眼内转运动力学特性的影响[J].中国中药杂志,2011,36(19):2723-2726. |
| 作者姓名： | 何群 王适 张湘晖 张健 姜宇 许江丽 |
| 作者单位： | 1. 湖南中医药大学中药药剂学重点学科湖南中医药大学中药现代化实验室,湖南长沙,410208 2. 湖南中医药大学第二临床学院,湖南长沙,410005 3. 湖南中医药大学第一临床学院,湖南长沙,410007 |
| 摘 要： | 目的:从药动学角度探索蜂蜜增强阿昔洛韦(ACV)治疗单纯疱疹病毒性角膜炎(HSK)药效的作用机制,为2药合用处方及给药方案设计提供依据.方法:分别单次给予兔眼内含5％蜂蜜和0％蜂蜜的目安眼膏,于不同时间取兔眼房水,高效液相色谱法测房水内ACV含量,建立数学模型,通过数学及统计学处理提取药动学参数,比较各参数差异.结果:含5％蜂蜜和0％蜂蜜的目安眼膏在兔眼内的转运均属于二室模型,含5％蜂蜜的目安眼膏在房水中吸收半衰期为不含蜂蜜目安眼膏的2.30倍,分布半衰期为2.12倍,达峰浓度为1.17倍,达峰时间为1.36倍,AUC为1.41倍.结论:蜂蜜可显著提高ACV在眼内的浓度及生物利用度,延长ACV在靶细胞内的作用时间,提高ACV在靶分子的滞留能力,使ACV在靶组织药效持久,从而提高疗效. |
| 关 键 词： | 蜂蜜 阿昔洛韦(ACV) 单纯疱疹病毒性角膜炎(HSK) 高效液相色谱法(HPLC) 二室模型 |
| 收稿时间： | 2010/4/11 0:00:00 |
Effects of honey to acyclovir in the rabbit eye transport kinetics |
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| HE Qun,WANG Shi,ZHANG Xianghui,ZHANG Jian,JIANG Yu and XU Jiangli.Effects of honey to acyclovir in the rabbit eye transport kinetics[J].China Journal of Chinese Materia Medica,2011,36(19):2723-2726. | |
| Authors: | HE Qun WANG Shi ZHANG Xianghui ZHANG Jian JIANG Yu and XU Jiangli |
| Institution: | Hunan University of Traditional Chinese Medicine and Drug Traditional Chinese Medicinal Pharmaceutics Key Subjects, Hunan University of Traditional Chinese Medicine and Drug Modernization Laboratory of Traditional Chinese Medicine and Drug, Changsha 410208, China;Second Clinical College of Hunan University of Chinese Medicine, Changsha 410005, China;First Clinical College of Hunan University of Chinese Medicine, Changsha 410007, China;First Clinical College of Hunan University of Chinese Medicine, Changsha 410007, China;Hunan University of Traditional Chinese Medicine and Drug Traditional Chinese Medicinal Pharmaceutics Key Subjects, Hunan University of Traditional Chinese Medicine and Drug Modernization Laboratory of Traditional Chinese Medicine and Drug, Changsha 410208, China;Hunan University of Traditional Chinese Medicine and Drug Traditional Chinese Medicinal Pharmaceutics Key Subjects, Hunan University of Traditional Chinese Medicine and Drug Modernization Laboratory of Traditional Chinese Medicine and Drug, Changsha 410208, China |
| Abstract: | |
| Keywords: | toney acyclovir (ACV) HSK HPLC two-compartment model |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |