| 姜黄素下调神经病理性疼痛大鼠脊髓背角和背根节CX3CR1的表达 |
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| 引用本文： | 郑晋伟,郑昌健,曹红,李军,连庆泉.姜黄素下调神经病理性疼痛大鼠脊髓背角和背根节CX3CR1的表达[J].中国中药杂志,2011,36(18):2552-2556. |
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| 作者姓名： | 郑晋伟 郑昌健 曹红 李军 连庆泉 |
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| 作者单位： | 1. 温州医学院附属第二医院麻醉科,浙江温州,325027
2. 温州医学院附属第二医院麻醉科,浙江温州325027;温州医学院疼痛医学研究所,浙江温州325027 |
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| 基金项目： | 国家自然科学基金项目(81073125);浙江省科技厅重大专项重点项目(2006C14027);浙江省自然科学基金项目(Y2090252);浙江省温州市科技局对外合作项目(Y2007A194) |
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| 摘 要： | 目的:观察姜黄素对坐骨神经慢性压迫性损伤(CCI)大鼠痛行为及脊髓背角和背根节趋化因子受体CX3CR1表达的影响.方法:雄性SD大鼠72只,随机分为假手术组(Sham组)、CCI组、姜黄素组(Cur组)、溶剂对照组(SC组).各组分别于术前2d和术后1,3,5,7,10,14 d测定大鼠后足热缩足反射潜伏期(TWL)和机械缩足反射阈值(MWT)；在术后3,7,14 d处死大鼠(n=6),分别制备大鼠L4-5节段脊髓和背根节的石蜡标本,用免疫组织化学法测定CX3CR1在脊髓背角和背根节的动态变化.结果:与Sham组比较,CCI组术后各时间点TWL,MWT明显降低(P＜0.01),且在术后3d都降至最低；与CCI组比较,Cur组术后7,10,14 d TWL明显增高(P＜0.05),术后10,14 d MWT明显增高(P＜0.05).同时,CCI大鼠术侧脊髓背角浅层和背根节的CX3CR1阳性细胞数明显增多,而姜黄素能够明显减少CX3CR1阳性细胞的表达.结论:姜黄素能减轻神经病理性疼痛,其机制可能与减少脊髓背角和背根节CX3CR1的表达有关.
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| 关 键 词： | 姜黄素 神经病理性疼痛 脊髓背角 背根节 小胶质细胞 CX3CR1蛋白 |
| 收稿时间： | 2010/10/8 0:00:00 |
Curcumin down-regulates CX3CR1 expression in spinal cord dorsal horn and DRG in neuropathic pain rats |
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| ZHENG Jinwei,ZHENG Changjian,CAO Hong,LI Jun and LIAN Qingquan.Curcumin down-regulates CX3CR1 expression in spinal cord dorsal horn and DRG in neuropathic pain rats[J].China Journal of Chinese Materia Medica,2011,36(18):2552-2556. |
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| Authors: | ZHENG Jinwei ZHENG Changjian CAO Hong LI Jun and LIAN Qingquan |
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| Institution: | Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China;Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China;Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China;Pain Institute of Wenzhou Medical College, Wenzhou 325027, China;Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China;Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China;Pain Institute of Wenzhou Medical College, Wenzhou 325027, China |
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| Abstract: | |
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| Keywords: | curcumin neuralgia spinal cord dorsal root ganglion microglia CX3CR1 protein |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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