| 海洋红树林微生物土曲霉的代谢产物研究 |
| |
| 引用本文： | 申毅,邹建华,戴均贵. 海洋红树林微生物土曲霉的代谢产物研究[J]. 中国中药杂志, 2011, 36(18): 2515-2519 |
| |
| 作者姓名： | 申毅 邹建华 戴均贵 |
| |
| 作者单位： | 中国医学科学院&北京协和医学院药物研究所,卫生部天然药物生物合成重点实验室&中草药物质基础与资源利用教育部重点实验室,北京100050 |
| |
| 基金项目： | "十一五"科技部国家"新药创制重大"专项(2009ZX09301-003-4-1)及国家自然科学基金项目(20602042);药物研究所基本科研业务费专项(2007CHX08) |
| |
| 摘 要： | 目的:从海洋红树林微生物的代谢产物中寻找抗肿瘤活性化合物.方法:用人工海水培养基培养海洋红树林微生物土曲霉,对其代谢产物进行提取分离,应用现代波谱学分析方法鉴定化合物.结果:从海洋红树林微生物土曲霉的代谢产物中分离得到12个单体化合物.结论:化合物1～4为甾体类化合物,5～8为有机酸和酯类,9为生物碱,10为香豆素类,11为神经酰胺类,12为丙烯基环戊二醇.
|
| 关 键 词： | 海洋微生物 土曲霉 代谢产物 |
| 收稿时间： | 2010-12-21 |
Studies on metabolites from marine microorganism Aspergillus terreus collected from nature reserve region of mangrove |
| |
| SHEN Yi,ZOU Jianhua and DAI Jungui. Studies on metabolites from marine microorganism Aspergillus terreus collected from nature reserve region of mangrove[J]. China Journal of Chinese Materia Medica, 2011, 36(18): 2515-2519 |
| |
| Authors: | SHEN Yi ZOU Jianhua DAI Jungui |
| |
| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key laboratory of Biosynthesis of Natural Products, Ministry of Public Health, Key laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China;Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key laboratory of Biosynthesis of Natural Products, Ministry of Public Health, Key laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China;Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key laboratory of Biosynthesis of Natural Products, Ministry of Public Health, Key laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China |
| |
| Abstract: | Objective: To search for new antitumor active lead compounds from marine microorganism.Method: A marine strain,Aspergillus terreus,was cultured and up-scaled in artificial seawater media,from which the metabolites were isolated and elucidated by using modern spectroscopy techniques.Result: Twelve compounds were isolated from mycelia and fermentation broth of A.terreus.Conclusion: Compounds 1-4 were steroids,compounds 5-8 were organic acids and esters,compound 9 was an alkaloid,compound 10 was an isocoumarin... |
| |
| Keywords: | marine microorganism Aspergillus terreus metabolites |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
|
