近视患者角膜横径与眼球其他参数的相关性分析

背景 近视患者角膜横径数据用途广泛,但其与眼球其他参数的相关性各研究结论不同.目的 探讨近视患者角膜横径与眼球其他参数的相关性. 方法 连续性纳入2012年2月至2013年2月在郑州大学第一附属医院眼科就诊的近视患者310例310眼,性别、年龄、等效球镜度、角膜地形图等数据.采用易俪统计学软件对资料进行处理,分析右眼角膜横径与性别、年龄、等效球镜度、角膜曲率、角膜散光、中央角膜厚度（CCT）和前房深度的关系. 结果 近视患者右眼角膜横径分布在10.8～ 13.5 mm,平均（11.7±3.8）mm.男女之间的角膜曲率和前房深度差异均有统计学意义（t=-1.574,P＜0.001;t=-1.145,P=0.034）.经平滑曲线拟合、阈值效应分析、单因素相关分析和多因素相关分析,角膜曲率与角膜横径为负向线性相关（β=-0.085,P=0.011）;前房深度与角膜横径为正向线性相关（β=0.722,P＜0.001）;角膜横径与近视等效球镜度、角膜散光、CCT和性别等参数均无相关性（β=0.000、0.084、-0.001、0.105,P＞0.05）,而年龄与角膜横径为存在拐点的曲线关系,且男女间的拐点不同. 结论 6 ～ 50岁近视患者的角膜横径与角膜曲率呈线性负相关,与前房深度呈线性正相关;角膜横径与性别、近视等效球镜度、角膜散光和CCT等参数无相关;与年龄存在拐点的曲线关系.

The correlation analysis between the corneal horizontal diameter and other parameters of the myopic eye

Background The parameter of corneal diameter in myopic eyes is widely used in clinic,but there are different points of view about the correlation of corneal horizontal diameter with other parameters of the myopic eye.Objective This study was to investigate the relevance of the other parameters to the corneal horizontal diameter（CHD）of myopia.Methods A total of 310 cases（310 eyes）of myopic patients aged 6-50 years old who visited Affiliated First Hospital of Zhengzhou University were collected for the study.Measuring items included gender,age,myopia diopter and corneal topography.The relationships between the CHD of the right eyes and seven factors including age,gender,degree of myopia,corneal curvature （CC）,corneal astigmatism （CS）,corneal central thickness（CCT）,and anterior chamber depth （ACD）were analyzed by empower stats software.Results The distribution range of CHD was from 10.8 mm to 13.5 mm,with the average value （11.7±3.8）mm.There were significant differences in the CC and ACD between male and female patients by t test（t =-1.574,P〈0.001 ;t=-1.145,P =0.034）.Through the smoothing curve fitting,the threshold effect and single factor and multiple regression analysis,the CHD was negative linear relationship with CC （β =-0.085,P =0.011）.The ACD positive linear relationship with CHD was found （β=0.722,P〈0.001）.And the CHD was not correlated with the degree of myopia,CS,CCT and gender（β =0.000,0.084,-0.001,0.105;all at P〉0.05）.There was different inflection point in the curve relationship between male patients and female patients.Conclusions The CHD is linear negatively correlated with CC and line positively associated with ACD in 6-50 years old myopic patients.There is no relationship between CHD and gender,spherical equivalent degree,CS,CCT.There is curvilinear relationship with inflection point between CHD and age.