CXC型趋化因子受体4及其分子显像剂在肿瘤方面的研究进展

CXC型趋化因子受体4（CXCR4）及CXC型趋化因子配体12（CXCL12）在肿瘤生长、新生血管形成和远处转移等方面发挥了至关重要的作用。两者结合后可以激活下游信号通路，从而发挥促进肿瘤生长和血管生成的作用。肿瘤组织高表达CXCR4，而肿瘤较常发生转移的部位高表达CXCL12，两者之间可通过特异性的结合而促使肿瘤发生转移。因此，CXCR4的表达水平在肿瘤转移的诊断方面具有预示性的作用，而无创性的影像学诊断方法，如SPECT/CT、PET显像等，有望在CXCR4的显像方面发挥重要作用，从而实现肿瘤的早期诊断和早期治疗。

Research progress of CXC chemokine receptor type 4 and molecular imaging in tumors

CXC chemokine receptor type 4 （CXCR4） and its ligand （CXCL12） exerts crucial influence in regulating tumor growth, angiogenesis and metastasis. Studies show that the downstream sig-naling pathway can be activated by interaction of the chemokine receptor and its ligand to promote tumor growth and angiogenesis. Additional observation suggests that neoplastic tissue expresses high levels of CXCR4, and the site of tumor metastasis over expresses CXCL12, through which this specific binding abil-ity can induce tumor metastasis. Thus, the CXCR4 levels could be used as a predictive marker of metastat-ic potential. Hopefully, the non-invasive imaging methods, such as SPECT/CT, PET, are employed in the imaging of the chemokine receptors to diagnose and treat the tumors in the early stage.