慢性气道阻塞者FEV_1、PEFR和V_(50)的改变

测定慢性气道阻塞(CAO)缓解期病人177例(40例慢性支气管炎、46例支气管哮喘、45例肺气肿和46例肺心病)和正常非吸烟者41例的FEV_1 、PEFR和V_(50)。3项指标在正常组与4组病人组间有显著差异性,5组间3项指标T_2检验,除慢支与支哮组间差异不显著外,其他任何两组间差异非常显著,五组中任一项指标均有显著差异性。各指标对任两组的比较,除慢支与支哮组间FEV_1、PEFR差异不显著,慢支与支哮、支哮与肺气肿组间V_(50)差异不显著外,其余各指标对任何两组均有非常显著的差异性。认为FEV_1是考核CAO最敏感的指标。

Changes of FEV_1, PEFR and V_(50) in chronic airway obstruction (CAO)

FEV_1, PEFR and V_(50) were measured in 177 patients with CAO in remission who were divided into four groups, chronic bronchitis 40, asthma 46, emphysema 45, cor putmonale 46, and one control group (41 healthy nonsmokers) The results of FEV_1, PEFR and V_(50) were compared and analysed. The difference of three indexes was statistically significant in the controls and patients. T~2 test of three indexes showed significant difference in the five groups except that in the groups of chronic bronchitis and asthma. Any of the three indexes had significant difference in the five groups. The rest were statistically significant in any two groups except FEV, PEFR in chronic bronchitis and asthma, V_(50) in chronic bronchitis and asthma, and in asthma and emphysema. We concluded that FEV_1 is the most sensitive of the three indexes for CAO.