小儿先天性心脏病体外循环术后毛细血管渗漏综合征的影响因素

目的探讨小儿先天性心脏病体外循环术后发生毛细血管渗漏综合征(capillary leak syndrome，CLS)的相关影响因素,为预防和控制CLS的发生提供依据。 方法收集2004 01—2005 12重庆医科大学附属儿童医院310例先天性心脏病体外循环(CPB)术后患儿的临床资料，对可能引起CLS发生的因素进行单因素分析和多元Logistic逐步回归分析，确定出与CLS发病相关的独立影响因素。 结果体外循环术后CLS的发生率为16.78%，病死率为19.23%。多元Logistic回归分析显示体外循环时间、心脏畸形的种类(单纯型/复杂型)、CPB术中最低温度、年龄是CLS发生的独立影响因素。 结论患儿的体外循环时间、心脏畸形的种类、术中最低温度、年龄是CLS发生的独立影响因素。

Analysis of influencing factors for capillary leak syndrome in children after cardiopulmonary bypass.

AbstractObjectiveTo determine influencing factors of capillary leak syndrome after cardiopulmonary bypass in children with congenital heart disease and offer reference for the prevention and control of CLS. MethodsClinical data were collected from children who underwent cardiopulmonary bypass in our hospita1 between January 2004 and November 2005.Several statistically significant influencing factors were screened out with univarite analysis，independent influencing factors of CLS were determined with multivarite stepwise logistic regression analysis. ResultsThe morbidity and mortality rate of CLS was 16.78% and 19.23% respectively.Logistic analysis showed the influencing factors of CLS were duration of cardiopulmonary bypass,type of congenital heart disease,lowest temperature during CBP and age. ConclusionThe influencing factors of CLS in children after cardiopulmonary bypass are duration of cardiopulmonary bypass,type of congenital heart disease,lowest temperature during CBP and age.