血清CysC、Hcy、及β-HCG检测与妊娠期高血压疾病的相关性研究

目的探讨孕妇血清半胱氨酸蛋白酶抑制剂C（Cystatin C）、同型半胱氨酸（Hcy）、及β-HCG联合检测与妊娠期高血压疾病的相关性。方法选择健康晚孕妇女60例及妊娠期高血压疾病（hypertensive disorder complicating preg-nancy,HDCP）患者肾病组18例和妊娠期高血压疾病患者无肾病组35例,对其血清分别进行Cys C、Hcy、β-HCG的检测。结果妊娠期高血压疾病肾病组血清Cys C、Hcy水平明显高于无肾病组（P〈0.01）,两组均明显高于健康晚孕组（P〈0.01）;妊娠期高血压疾病肾病组及无肾病组β-HCG水平无明显差别（P〉0.05）,与健康晚孕组比较结果有统计学意义（P〈0.05）。结论血清Cys C、Hcy与β-HCG联合检测对了解妊娠期高血压疾病的病情具有重要意义。Cys C及Hcy与β-HCG比较在反映HDCP患者的肾损害及肾功能恢复方面更敏感,是反映HDCP病情及预后的良好指标。联合检测可作为了解HDCP的发生、发展及预后判断的指标。

The correlation study of serum cystatin C,Hcy,and beta-HCG testing and hypertensive disorder complicating pregnancy

Objective: Investigate the correlation of maternal serum Cystatin C,homocysteine(Hcy),β-HCG Joint detection and hypertensive disorder complicating pregnancy(HDCP).Methods: Choose 60 cases of healthy late pregnant women,18 cases of HDCP with kidney disease,and 35 cases of HDCP without kidney disease.Test the serum Cys C,Hcy,β-HCG.Results: The levels of serum Cys C and Hcy in group of HDCP with kidney disease are significantly higher than the group of HDCP without kidney disease(P<0.01).These two groups are significantly higher than the group of healthy late pregnant women(P<0.01).There is no significant difference between β-HCG′s level of group of HDCP with kidney disease and group of HDCP without kidney disease(P>0.05).The results are statistically significant that the two groups compare with the healthy late pregnant group(P>0.05).Conclusion: Joint detection of serum Cys C,Hcy,and β-HCG has great significance to understand the condition of HDCP.Comparison of Cys C,Hcy and β-HCG is sensitive in the respect of renal injury and renal function recovery,that is a good index to reflect the condition and prognosis of HDCP.The joint detection can be used as the indicator of occurrence,development and prognosis of HDCP.