体脂分布类型和胰岛素抵抗对心血管病危险因素聚集性的影响

目的探讨体脂分布类型和胰岛素抵抗对心血管病危险因素聚集性的影响。方法在2 668名自然人群中调查体质量指数、腰围/臀围比值、血压、血胆固醇、三酰甘油、高密度脂蛋白-胆固醇、低密度脂蛋白-胆固醇、血糖、胰岛素及胰岛素敏感性指数。结果外周型超重组血压、三酰甘油、胰岛素高于非超重组,高密度脂蛋白-胆固醇、胰岛素敏感性指数低于非超重组;而中心型超重组血压、胰岛素及危险因素聚集程度高于外周型超重组,胰岛素敏感性指数低于外周型超重组;分析显示胰岛素敏感性指数与血脂、血糖及危险因素聚集程度密切相关。结论体脂分布类型是影响心血管危险因素聚集的重要因素。

Influence of overweight pattern and insulin resistance on the clustering of cardiovascular risk factors

Objective To explore the relationship between overweight pattern and insulin resistance on the clustering of cardiovascular risk factors.Methods A survey was carried out in 2668 people in a rural population.Body mass index,waist-hip ratio,systolic and diastolic blood pressure,total cholesterol,triglyceride,high density lipoprotein cholesterol,fasting blood sugar,insulin and insulin sensitivity index.Results In the overweight group with central fat distribution,mean SBP,DBP,TC,TG,FBS,INS were singnificantly higher,whereas mean HDL-C,were signisxantly lower than those in non-overweight group with peripheral fat distribution.In the overweight group with central fat distribution,SBP,DBP,INS were also significantly higher,whereas mean ISI was also significantly lower than in the overweight group with peripheral fat distribution.The prevalences of hypertension,diabetes mellitus,hyperlipidemia and the degree of cluster of cardiovascular risk factors were also higher for central pattern than for peripheral pattern,what overweight or not.After controlling the effect of other variables,multivariant regression analysis revealed that the degree of cluster of cardiovascular risk factors was significantly correlated with insulin sensitivity index.Conclusion BMI,WHR and ISI may influence cardiovascular risk factors,but body fat distribution is an important factor influencing the cluster of cardiovascular risk factors and correlates with insulin resistance.