中药煎剂联合西药治疗94例异位妊娠患者的疗效观察

目的:观察中药煎剂联合西药治疗异位妊娠(EP)的疗效。方法:选取282例诊断为EP的患者,按照数字表法随机分成三组。其中,对照组B给予米非司酮治疗,对照组A给予米非司酮+甲氨蝶呤(MTX)治疗,观察组给予自拟中药煎剂+米非司酮+MTX治疗。观察三组总有效率、血中β-人绒毛膜促性腺激素(β-HCG)变化以及治疗期间不良反应发生情况。结果:治疗后观察组总有效率为92.55%,对照组A为65.96%,对照组B为53.19%,观察组与两对照组比较,差异具有统计学意义(P<0.05);观察组在治疗后第5天血β-HCG水平即出现明显下降,两对照组在治疗后第10天才出现明显下降,治疗后5、10 d的血β-HCG水平,两对照组与观察组比较,差异具有统计学意义(P<0.05);观察组不良反应发生率为12.77%,对照组A为30.85%,对照组B为34.04%,三组比较,差异有统计学意义(P<0.05)。结论:中药煎剂联合西药米非司酮、MTX治疗EP,总体疗效优于单纯西药治疗,且起效迅速、不良反应发生率低。

Efficacy Observation of TCM Decoction Combined with Western Medicine in the Treatment of 94 Ectopic Pregnancy Patients

OBJECTIVE： To observe therapeutic efficacy of TCM decoction combined with western medicine in the treatment of 94 ectopic pregnancy （EP） patients. METHODS： 282 patients diagnosed as EP were randomly divided into 3 groups. Control group B was given mifepristone, control group A was given mifepristone and MTX, and observation group was treated with TCM decoction, mifepristone and MTX. Total effective rate, the change of β-HCG and toxic side reaction were observed in 3 groups. RESULTS： Total effective rate was 92.55% in observation group, 65.96% in control group A and 53.19% in control group B; there was statistical significance between observation group and control groups （P〈0.05）. The level of fl-HCG in observation group was decreased significantly after 5 days of treatment, and those of control groups were decreased significantly after 10 days of treatment; there were statistical significance in the level of β-HCG between observation group and control groups after 5 and 10 days of treatment （P〈0.05）. The incidence of ADR was 12.77% in observation group, 30.85% in control group A and 34.04% in control group B; there was statistical significance （P〈0.05）. CONCLUSIONS： The overall effect TCM decoction combined with mifepristone and MTX is better than western medicine alone in the treatment of EP, and have quick effect and low incidence of ADR.