芎姜超临界CO_2提取物透皮凝胶的经皮渗透研究

目的:研究川芎、炮姜超临界CO2提取物透皮凝胶(简称芎姜超临界CO2提取物凝胶)的经皮渗透性。方法:通过透皮扩散仪测定芎姜超临界CO2提取物凝胶经离体大鼠皮肤的渗透性,分别以藁本内酯、6-姜酚为指标成分,高效液相色谱(HPLC)法测定药物含量求算累积渗透量(Q)与稳态透皮速率(JS)。结果:芎姜超临界CO2提取物凝胶中藁本内酯和6-姜酚均能有效经皮渗透,Js分别为(47.57±3.77)、(8.29±1.47)μg/(cm2·h),14 h平均累积渗透百分数分别为(26.99±1.89)%和(14.40±1.18)%。结论:芎姜超临界CO2提取物凝胶具有良好的经皮渗透性,经皮给药有望作为芎姜超临界CO2提取物的一种新给药途径。

Transdermal Penetration of Hydrogel Containing Xiongjiang CO2-SFE in vitro

OBJECTIVE： To study the transdermal permeation of hydrogel containing CO2-SFE of Ligusticum chuanxiong and Zingiber officinale（called Hydrogel containing Xiongjiang CO2-SFE for short）. METHODS： The transdermal permeation of Hydrogel containing Xiongiiang CO2-SFE was determined by transdermal diffusion device, with ligusti＇lide and 6-shogaol as indicators. Accumulative transdermal quantity and static percutaneous rate of drugs were determined by HPLC. RESULTS：The results showed that ligustilide and 6-shogaol could both permeate across the rat skin in vitro; static percutaneous rate of them were （47.57 ± 3.77） μg/ （cm2· h） and （8.29± 1.47） μg/（cm2·h） ; 14 h average accumulative permeation percentages were （26.99 ± 1.89） % and （14.40 ± 1.18）%, respectively. CONCLUSIONS： The results show good transdermal permeation of Hydrogel containing Xiongjiang CO2-SFE. The percutanous administration is a potential route of administration for Xiongjiang CO2-SFE.