不同剂量的阿托伐他汀钙对血脂正常的高血压患者血管内皮功能的影响

目的:观察不同剂量的阿托伐他汀钙对血脂正常的高血压患者血管内皮功能的影响。方法:将98例血脂正常的高血压患者按随机数字表法均分为A、B组,另设健康对照组30例。A、B组患者均按入组前的降压治疗方案继续用药,在此基础上,A组患者给予阿托伐他汀钙10 mg,qd;B组患者给予阿托伐他汀钙20 mg,qd。两组患者均用药4周。观察治疗前后两组患者的血脂水平、内皮依赖性血管舒张功能(FMD)、内皮非依赖性血管舒张功能(EID)和不良反应发生情况,并与健康对照组比较。结果:两组患者的血脂水平治疗前、后同组及组间比较,差异均无统计学意义(P>0.05)。治疗前,两组患者的FMD和EID水平均显著低于健康对照组。治疗后,两组患者的FMD水平均显著高于本组治疗前,且B组患者的FMD改善程度优于A组,差异均有统计学意义(P<0.05);但两组患者的EID水平与治疗前比较差异均无统计学意义(P>0.05)。两组患者治疗后的FMD和EID水平仍显著低于健康对照组,差异均有统计学意义(P<0.05)。两组患者的不良反应均少见且轻微。结论:阿托伐他汀钙具有改善血脂正常的高血压患者血管内皮功能的作用,且效果可能呈剂量依赖性。

Effects of Different Doses of Atorvastatin Calcium on Endothelial Function in Hypertension Patients with Normal Blood Lipid

OBJECTIVE： To observe the effects of different doses of atorvastatin calcium on endothelial function in hypertension patients with normal blood lipid. METHODS： 98 hypertension patients with normal blood lipids were randomly divided into group A and group B. Other 30 patients were included in healthy control group. 2 groups were give medicines according to previous anti-hypertension plan. Group A was given atorvastatin calcium 10 mg, and group B was treated with atorvastatin calcium 20 mg. Treatment course of both groups lasted for 4 weeks. The blood fat vasodilation （FMD） and endothelium non-dependent vasodilation （EID） were observed in 2 groups before and after treatment, and compared with the healthy control group. RESULTS： There was no statistical significance in the level of blood fat of 2 groups in same group, and the level between 2 groups before and after treatment（P〉0.05）. Before treatment, FMD and EID of both groups were significantly lower than those of healthy control group. After treatment, FMD of both groups were significantly higher than before, and the improvement of FMD in group B was better than in group A; there were statistical significance （P〈0.05） ; there was no statistical significance in EID of 2 groups before and after treatment （P〉0.05）. FMD and EID of 2 groups were significantly lower than those of healthy control group after treatment; there was Statistical significance （P〈0.05）. Adverse drug reactions were mild in two groups. CONCLUSIONS： Atorvastatin calcium has improved endothelial function in hypertension patients with normal blood lipid may be related to measurement.