利巴韦林致过敏性休克31例文献分析

目的:探讨利巴韦林致过敏性休克的规律和特点,为临床合理用药提供参考。方法:检索相关数据库收载国内期刊中涉及利巴韦林致过敏性休克的病例资料,对获得的31例不良反应病例的相关情况进行统计与分析。结果:31例利巴韦林致过敏性休克均为静脉滴注和肌肉注射给药,未成年患者占比较高;以速发型过敏性休克为主;循环系统、中枢神经系统和呼吸系统损害较多见;存在较多的不合理联合用药情况;8例患者死亡,23例患者经治疗后恢复正常。结论:利巴韦林致过敏性休克可造成严重后果,临床应加强对此种严重不良反应的监测。

Analysis of 31 Cases of Allergic Shock Induced by Ribavirin

OBJECTIVE： To investigate the regularity and characteristics of allergic shock induced by fibavirin, and to provide reference for rational drug use in the clinic. METHODS： Literatures about allergic shock induced by ribavirin were retrieved from domestic journals included in related database. 31 cases of ADR were analyzed statistically. RESULTS： 31 cases of allergic shock induced by ribavirin were intravenous dripping and Intramuscular injection, and minor patients occupied high proportion. They were mainly immediate allergic shock, and the major manifestations were circulatory system injury, nervous system injury and respiratory system injury. There were many cases of irrational drug use. There were 8 death cases, and 23 cases were recovered after treatment. CONCLUSIONS： Allergic shock induced by ribavirin causes serious result, and great importance should be attached to severe ADR monitoring.