1611例药品不良反应报告分析

目的:了解我院药品不良反应(ADR)的发生特点及规律。方法:对我院2005-2013年收集并上报国家ADR监测中心的ADR报告1 611例,按患者性别、年龄、给药途径、药品种类、ADR累及器官或系统及临床表现等进行统计、分析。结果:1 611例ADR报告中,女性(890例)多于男性(721例),但差异无统计学意义(P>0.05);60岁以上患者发生ADR最多,占52.70%;引起ADR最多的给药途径为静脉滴注,占77.53%;由抗感染药引发的ADR最多,占28.18%;其中,头孢菌素类药物引起ADR最多,占35.90%;ADR累及器官或系统以皮肤及其附件损害最为常见,占37.31%;严重的ADR有4例。结论:临床应重视ADR的监测工作,尤其是抗感染药,以避免或减少ADR的发生。

Analysis of 1 611 Cases of ADR Reports

OBJECTIVE： To investigate the characteristics and regularity of ADR in our hospital. METHODS： 1 611 cases of ADR reported during 2005-2013 in our hospital were analyzed statistically in terms of patients＇ gender, age, route of administration, drug variety, organs or systems involved in ADR and clinical manifestations, etc. RESULTS： Of the total 1 611 ADR cases, female （890 cases） showed higher proportion than male （721 cases） while there was no significant difference between female and male （P〉0.05）. The largest proportion of ADR cases occurred in patients aged more than 60 years old, accounting for 52.70% ; most of ADR cases were induced by intravenous dripping, accounting for 77.53% ;most of ADR were induced by anti-infection drugs, accounting for 28.18%; among the anti-infection drugs, the most was cephalosporin, accounting for 35.90%; the most common clinical manifestations were the damage of skin and appendants, accounting for 37.31% ; there were 4 cases of severe ADR. CONCLUSIONS： Great importance should be attached to ADR monitoring, especially to the anti-infection drug, so as to avoid or reduce the occurrence of ADR.