葛根芩连汤对2型糖尿病模型大鼠的降糖作用

目的:研究葛根芩连汤对2型糖尿病模型大鼠的降糖作用。方法:高脂饲料喂饲联合腹腔注射链脲佐菌素以复制大鼠2型糖尿病模型。120只SD大鼠随机均分为正常对照(等容生理盐水)组、模型(等容生理盐水)组、二甲双胍(0.3 mg/kg)组与葛根芩连汤①、②、③、④、⑤、⑥、⑦、⑧、⑨(28.05、24.75、21.45、18.15、14.85、11.55、8.25、4.95、1.65 g/kg)组。灌胃给药,每天1次,连续8周。测定大鼠血糖(FBG)、糖化血红蛋白(HbAlc)、糖化血清蛋白(GSP)、胰岛素(Fins)与胰岛素抵抗指数(IRI)。结果:与模型组比较,葛根芩连汤①、②、③、④、⑤、⑥、⑦、⑧组大鼠FBG、HbAlc、GSP、Fins、IRI降低,差异有统计学意义(P<0.01)。葛根芩连汤起效剂量范围为4.95²8.05g/kg。结论:葛根芩连汤对2型糖尿病模型大鼠具有良好的降糖作用,且呈量效关系。

Hypoglycemic Effect of Gegen Qinlian Decoction on Type 2 Diabetes Rats

OBJECTIVE： To study the hypoglycemic effect of Gegen qinlian decoction on type 2 diabetes rats. METHODS： Type 2 diabetes model was induced by high fat diet combined with intraperitoneal injection of STZ. 120 SD rats were randomly divided into normal control group （constant volume of normal saline） , model group （constant volume of normal saline） metformin group （0.3 mg/kg） and Gegen qinlian decoction ①,②,③,④,⑤,⑥,⑦,⑧ and ⑨ groups （1.65, 4.95, 8.25, 11.55, 14.85, 18.15, 21.45, 24.75, 28.05 g/kg）. They were given relevant medicines intragastrically once a day for consecutive 8 weeks. FBG, HbAlc, glycosylated serum protein （GSP）, insulin （Fins） and insulin resistance index （IRI） were all determined. RESULTS： Compared with model group, FBG, HbAlc, GSP, Fins and IRI decreased in Gegen ainlian decoction ①,②,③,④,⑤,⑥,⑦,⑧ groups; there was statistical significance （P〈0.01 or P〈0.05）. There was dose-effect relationship of Gegen qinlian decoction with hypoglycemic doses, with effective dose range of 4.95-28：05 g/kg. CONCLUSIONS： Gegen qinlian decoction has good treatment effect on type 2 diabetes model rat, and shows a certain dose-effect relationship.