| 正交试验优选白芷中总香豆素的超声提取工艺 |
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| 引用本文： | 邱婧然,王志祥,周黎明. 正交试验优选白芷中总香豆素的超声提取工艺[J]. 中国药房, 2014, 0(7): 618-620 |
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| 作者姓名： | 邱婧然 王志祥 周黎明 |
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| 作者单位： | [1]湖北医药学院,湖北十堰442000 [2]中国药科大学药学院,南京210009 [3]阿斯利康制药有限公司,江苏无锡214028 |
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| 基金项目： | 湖北医药学院研究生启动基金（自然科学研究）资助计划项目[湖医药科字（201215号] |
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| 摘 要： | 目的:优选白芷中总香豆素的超声提取工艺。方法:以香豆素得率和香豆素纯度为指标,以超声功率、提取时间、提取温度、占空比和液固比为考察因素,采用正交试验优选白芷中总香豆素的超声提取工艺。结果:优选工艺为超声功率800 W,提取时间20 min,提取温度50℃,占空比5∶1,液固比40∶1(ml/g);在该工艺条件下,香豆素得率为0.236%,纯度为11.69%。结论:所选工艺稳定、可行,可用于白芷中总香豆素的超声提取。
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| 关 键 词： | 白芷 香豆素 超声提取 正交试验 |
Optimization of Ultrasonic Extraction Technology of Total Coumarins from Angelica dahurica by Orthogonal Test |
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| QIU Jing-ran,WANG Zhi-xiang,ZHOU Li-ming. Optimization of Ultrasonic Extraction Technology of Total Coumarins from Angelica dahurica by Orthogonal Test[J]. China Pharmacy, 2014, 0(7): 618-620 |
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| Authors: | QIU Jing-ran WANG Zhi-xiang ZHOU Li-ming |
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| Affiliation: | 1.Hubei Medical University, Hubei Shiyan 442000, China; 2. School of Phamacy, China Pharmaceutical University, Nanjing 210009, China; 3.Astra Zeneca Pharmaceutical Co., Ltd.,Jiangsu Wuxi 214028, China) |
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| Abstract: | OBJECTIVE： To optimize the ultrasonic extraction process of total coumarins from Angelica dahurica. METHODS： The ultrasonic extraction technology was optimized by orthogonal test with ultrasound power, extraction temperature, extraction time, on/off ratio and liquid/solid ratio as factors using the yield and purity of coumarins as index. RESULTS： The optimal extrac- tion conditions was as follows： ultrasound power 800 W, extraction time 20 rain, extraction temperature 50 ℃, on/off ratio 5 ： 1, liquid/solid ratio 40：1 ml/g. Under the above conditions, coumarins yield was 0.236% while purity 11.69 %. CONCLUSIONS： The optimized process conditions are stable and practicable, and can be used for ultrasonic extraction of total coumarins from A. dahurica. |
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| Keywords: | Angelica dahurica Coumarins Ultrasonic extraction Orthogonal test |
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