多潘立酮联合香砂六君丸治疗功能性消化不良的临床观察

目的:观察多潘立酮联合香砂六君丸治疗功能性消化不良(FD)的临床疗效和安全性。方法:将106例FD的住院患者采用抽签方式随机均分为研究组和对照组。研究组患者口服多潘立酮片10 mg/次,tid,并口服香砂六君丸6 g/次,tid;对照组患者仅口服多潘立酮片10 mg/次,tid。两组患者均治疗4周。观察两组患者治疗前后的临床症状评分、总积分、临床疗效及不良反应发生情况。结果:治疗后,两组患者食欲不振、上腹不适、腹胀、餐后早饱、恶心呕吐、嗳气等临床症状评分均较治疗前显著下降,且研究组患者除上腹不适外,其他症状评分显著低于对照组,差异均有统计学意义(P<0.05),研究组患者临床症状总积分下降值和下降比例显著高于对照组,差异均有统计学意义(P<0.05);研究组患者总有效率显著高于对照组,差异有统计学意义(P<0.05);两组患者均未见明显不良反应发生。结论:多潘立酮联合香砂六君丸治疗FD的疗效显著优于单用多潘立酮,且安全性较好。

Clinical Observation of Domperidone Combined with Xiangsha Liujun Pills in the Treatment of Functional Dyspepsia

OBJECTIVE： To observe clinical efficacy of domperidone combined with Xiangsha liujun pills in the treatment of functional dyspepsia. METHODS： 106 inpatients with functional dyspepsia were randomly divided into treatment group and control group. Treatment group was given Domperidone tablets 10 mg/times and Xiangsha liujun pills 6 g/times orally. Control group was only given Domperidone tablet orally 10 mg/times. Treatment course of 2 groups lasted for 4 weeks. The clinical symptom score, clinical efficacy and ADR were observed after treatment. RESULTS： Compared with before treatment, the clinical symptom score of 2 groups were significantly decreased after treatment, such as anorexia, epigastric discomfort, abdominal distension, early satiety after meal, nausea and vomiting, belching; the score of anorexia, abdominal distension, early satiety after meal, nausea and vomiting, belching in treatment group were significantly lower than in control group after treatment; the range and ratio of the decrease of total score of clinical symptom in treatment group were significantly higher than in control group; there was statistical significance （P〈0.05）. The total effective rate of treatment group was significantly higher than that of control group; there was statistical significance （P〈0.05）. No significant ADR was found in 2 groups. CONCLUSIONS： Domperidone combined with Xiangsha liujun pills is better and safer than domperidone alone in the treatment of functional dyspepsia.