Nuclear omnipotent suppressors of premature termination codons in mitochondrial genes affect the 37S mitoribosomal subunit |
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Authors: | Magdalena Boguta Maria Mieszczak Wlodzimierz Zagórski |
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Institution: | (1) Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Rakowiecka 36 street, PL-02-532 Warsaw, Poland |
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Abstract: | Summary nam3 and R705, yeast nuclear omnipotent suppressors of mitochondrial mit
– mutations, reverse the superimposed spectrum of trans-recessive splicing defects by affecting the protein composition of the small mitoribosomal subunit. Analysis of the suppressor's interaction suggests that suppression results from mutations in the mitoribosomal polypeptides. These data indicate an obligatory connection between mitoribosome function and splicing of introns bI2, bI4 and aI1 in yeast mitochondria. |
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Keywords: | Mitochondrial ribosomes Suppressor nam mutants |
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