Bowen's disease showing spontaneous complete regression associated with apoptosis |
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| Authors: | M Chisiki,A Kawada,M Akiyama,Y Itoh,S Tajima,A Ishibashi,& F Yudate |
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| Affiliation: | Department of Dermatology, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359-0042, Japan. |
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| Abstract: | Spontaneous regression is sometimes seen in malignant skin tumours. We report a 68-year-old woman whose Bowen's disease showed spontaneous complete regression. Prominent infiltration of T cells and increased vascularity were found in the upper dermis of the regressed lesion. Strong expression of Fas (APO-1/CD95) antigen, an apoptosis-related tumour necrosis factor receptor family protein, in the primary lesion and faint expression following regression suggest the involvement of Fas-mediated apoptosis in the spontaneous complete regression of our patient's Bowen's disease. |
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| Keywords: | apoptosis Bowen's disease Fas antigen regression |
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