雌激素受体在肝癌组织中的表达及其临床意义

目的研究雌性激素受体(ER)在肝癌组织中的表达和其临床价值。方法采用免疫组化法对59例肝癌患者肝肿瘤组织中雌激素受体(ER)表达情况进行研究。结果 59例肝癌患者ER表达阳性率为72.9%。22～36岁的肝癌患者ER表达阳性率为72.22%(13/18),37～52岁的患者表达阳性率为75.01%(15/20),53～67岁的患者的阳性率为71.42%(15/21);直径≤5 cm的肝癌中ER表达阳性率为33.33%(6/18),直径大于5 cm的癌组织阳性率为90.24%(37/41);分化程度为EdmondsonⅠ级的肝癌组织中表达阳性率为96.97%(32/33),Ⅱ级的阳性率为55.56%(10/18),Ⅲ级阳性率为12.5%(1/8)。年龄组间表达差异无统计学意义(P>0.05),而不同大小肿瘤和不同分化程度组间表达差异有统计学意义(P<0.05)。结论原发性肝细胞癌具有一定的雌激素依赖性,肝癌发生、发展及预后与肝癌组织中ER表达有关。

Expression of estrogen receptor (ER) in hepatocellular carcinoma and its clinical value

Objective To study the expression of estrogen receptors(ER) in the hepatocellular carcinoma tissues and its clinical values.Methods The expression of ER in the hepatocellular carcinoma tissues was examined in 59 cases of liver cance patients by immunohistochemical method.Results The positive rates of ER expression were 72.9% in 59 hepatocellular carcinoma patients.however,the positive expression rates of ER were 72.22%(13/18) in patients whose age was 22-36,75.01 %(15/20) in patients whose age was 37-52,71.42 %(15/21)in patients whose age was 53-67;the positive expression rates of ER were 33.33%(6/18) in hepatocellular carcinoma patients(Tumor diameter ≤ 5 cm),the rates were 90.24%(37/41) in patients(Tumor diameter ﹥ 5 cm);the expression rates of ER were 96.97%(32/33) in EdmondsonⅠliver cancer,the rates were 55.56%(10/18) in Edmondson II and 12.5%(1/8) in Edmondson III cancer.Therefore,there are no significant difference in age based groups(P> 0.05),while the experession of ER have significant difference in tumor size based groups and in groups based on levels of pathologic differentiation.Conclusion Primary liver cancer maybe a estrogen dependent tumor,and the occurrence,development and prognosis of hepatocellular carcinoma may associated with ER expression.