外周血血小板计数及纤维蛋白原含量在上皮性卵巢癌诊治中的意义

目的]探讨外周血血小板（PLT）计数及血浆纤维蛋白原（FIB）与上皮性卵巢癌生物学行为的关系。方法]回顾性分析上皮性卵巢癌初次手术病例82例,并与同期收治的52例卵巢良性肿瘤作对照,比较两组术前血小板计数和纤维蛋白原含量。同时分析血小板计数和纤维蛋白原含量与上皮性卵巢癌生物学行为的关系。结果]术前上皮性卵巢癌患者血小板计数增高者占52.44%,良性肿瘤中占11.54%;在上皮性卵巢癌中血浆纤维蛋白原增高者占53.66%,而良性肿瘤中占7.69%,差异均有统计学意义（P=0.000）。血小板计数与上皮性卵巢癌的FIGO分期、腹水、分化程度、是否行理想的肿瘤细胞减灭术有关（P〈0.05）,与CA125及病理类型无关。血浆纤维蛋白原与上皮性卵巢癌的各项临床病理因素均无关（P〉0.05）。单因素及多因素分析结果显示血小板计数及纤维蛋白原均与卵巢癌复发无关。结论]血小板计数增高可能是反映上皮性卵巢癌浸润程度的指标。纤维蛋白原增高可能是卵巢癌的结果,其与血小板的关系有待于进一步研究。

Significance of Peripheral Blood Platelet Count and the Content of Plasma Fibrinogen(FIB) in the Diagnosis and Treatment of Epithelial Ovarian Cancer

Purpose] To investigate the relationship of peripheral blood platelet（PLT） count and the content of plasma fibrinogen（FIB） with biology behavior of epithelial ovarian cancer.Methods] Eighty-two primary surgical cases with epithelial ovarian cancer and 52 cases with ovarian benign tumors were analyzed retrospectively. PLT count and FIB content preoperation were compared between the two groups. And the correlation between PLT count or FIB content and biology behavior of epithelial ovarian cancer were analyzed. Results] patients with increasing PLT count preoperation accounted for 52.44% in epithelial ovarian cancer,which was11.54% in ovarian benign tumor;as for increasing plasma FIB,it was 53.66% in epithelial ovarian cancer,and 7.69% in ovarian benign tumor,both with significant difference（P=0.000）.PLT count was correlated with FIGO staging,ascites,pathological differentiation and optical cytoreductive surgery（P＆lt;0.05）,while was not correlated with CA125 and pathological types. Plasma FIB had no correlation with all the clinicopathologic factors of epithelial ovarian cancer（P＆gt;0.05）. Both univariate and multivariate analyses showed that PLT count and plasma FIB were not concerned with the recurrence of ovarian cancer.Conclusion] Increased platelet count is likely to be an indictor to reflect the invasion degree of epithelial ovarian cancer. Increased plasma fibrinogen could be the result of ovarian cancer and its relationship with platelet still needs further research.