中药抑制肿瘤上皮间质转化的研究

从中药单体和复方制剂两方面对中药抑制肿瘤上皮一间质转化（EMT）的研究进展作一整理，并总结了传统中医药与现代药理机制之间的关联，上皮-间质转化是上皮细胞通过特定的程序转化为间质细胞的生物学过程，在肿瘤的侵袭转移过程中起重要作用，但至今尚缺乏有效的治疗药物。中药单体成分及复合方剂抑制肿瘤EMT的基础和临床研究进行了很多，有些药物已经在临床中应用并经证实疗效确切，亦有些药物目前尚处于基础实验阶段，中药单体的作用机制较复方合剂进展迅速。但EMT的调控是个复杂的过程，需要寻找更加特异的靶点，特异性地抑制调控EMT的过程；同时需要积累更多的临床经验，兼顾临床疗效、不良反应及耐药现象。相信随着对EMT研究方法的不断改进和理论的完善，中药抑制EMT的研究必将受到越来越多的关注，对于实现中药现代化起到重要意义。

Research of Mechanism of Chinese Herbal Drug on Epithelial-mesenchymal Transition against Cancer

Epithelial-mesenchymal transition (EMT) refers to the process by which cells transit from epithelial phenotype to mesenchymal phenotype. It plays an important role in the invasion and metastasis of carcinomas,but lack of effective therapeutic drugs so far. Chinese material medica which is capable of inhibiting EMT in tumor with minimal adverse side effects, curative effects and multiple targets in an attractive resource library and has aroused more and more concern.The research is about the newest progress of effect and mechanism of Chinese herbal drug monomer and compound against cancer and summarizes the association between therapeutic principle of traditional Chinese medicine and modern pharmacological mechanisms,in order to provide some references and clues to the drug development for EMT.