Pharmacokinetics of propranolol in normal healthy volunteers |
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Authors: | Roberto Gomeni Gabrio Bianchetti Roberto Sega P. L. Morselli |
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Affiliation: | (1) Istituto di Ricerche Farmacologiche Mario Negri,, Milano, Italy;(2) Present address: Department of Clinical Research, Synthelabo, L.E.R.S., 58, rue de la Glacière, 75621 Paris Cedex 13, France;(3) Cattedra di Patologia Speciale Medica Ospedale Sacco, Università di Milano, Milano, Italy |
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Abstract: | The pharmacokinetics of propranolol in blood was studied in healthy volunteers, following intravenous administration of 0.1 mg/kg and increasing oral doses of 10,20, and 40 mg, using a specific and sensitive gas Chromatographie method. The systemic availability of orally administered propranolol varied from 9% to 38% between subjects, but it was constant within each subject. A linear relationship was found between the area under the blood concentration-time curve and the oral dose. At variance with literature data, we could not observe a threshold dose. |
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Keywords: | propranolol kinetics volunteers bioavailability threshold dose |
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